Lineage-associated underrepresented permutations (LAUPs) of mammalian genomic sequences based on a Jellyfish-based LAUPs analysis application (JBLA)

Bioinformatics
Le ZhangJun Yu

Abstract

This study addresses several important questions related to naturally underrepresented sequences: (i) are there permutations of real genomic DNA sequences in a defined length (k-mer) and a given lineage that do not actually exist or underrepresented? (ii) If there are such sequences, what are their characteristics in terms of k-mer length and base composition? (iii) Are they related to CpG or TpA underrepresentation known for human sequences? We propose that the answers to these questions are of great significance for the study of sequence-associated regulatory mechanisms, such cytosine methylation and chromosomal structures in physiological or pathological conditions such as cancer. We empirically defined sequences that were not included in any well-known public databases as lineage-associated underrepresented permutations (LAUPs). Then, we developed a Jellyfish-based LAUPs analysis application (JBLA) to investigate LAUPs for 24 representative species. The present discoveries include: (i) lengths for the shortest LAUPs, ranging from 10 to 14, which collectively constitute a low proportion of the genome. (ii) Common LAUPs showing higher CG content over the analysed mammalian genome and possessing distinct CG*CG motifs. (iii) Ne...Continue Reading

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Citations

May 29, 2019·PLoS Computational Biology·Le ZhangZhenglin Du
Jan 27, 2020·Briefings in Bioinformatics·Le ZhangMing Xiao
Aug 25, 2020·Interdisciplinary Sciences, Computational Life Sciences·Jiayidaer BadaiLe Zhang
Mar 17, 2019·Interdisciplinary Sciences, Computational Life Sciences·Jin LiLe Zhang
Mar 7, 2020·Computational and Structural Biotechnology Journal·Jingtian ZhaoLe Zhang

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