Lineage-guided Notch-dependent gliogenesis by Drosophila multi-potent progenitors

Development
Qingzhong RenTzumin Lee

Abstract

Macroglial cells in the central nervous system exhibit regional specialization and carry out region-specific functions. Diverse glial cells arise from specific progenitors in specific spatiotemporal patterns. This raises an interesting possibility that glial precursors with distinct developmental fates exist that govern region-specific gliogenesis. Here, we have mapped the glial progeny produced by the Drosophila type II neuroblasts, which, like vertebrate radial glia cells, yield both neurons and glia via intermediate neural progenitors (INPs). Distinct type II neuroblasts produce different characteristic sets of glia. A single INP can make both astrocyte-like and ensheathing glia, which co-occupy a relatively restrictive subdomain. Blocking apoptosis uncovers further lineage distinctions in the specification, proliferation and survival of glial precursors. Both the switch from neurogenesis to gliogenesis and the subsequent glial expansion depend on Notch signaling. Taken together, lineage origins preconfigure the development of individual glial precursors with involvement of serial Notch actions in promoting gliogenesis.

References

Jan 11, 2002·Developmental Biology·K J SeppV J Auld
Jun 8, 2002·Annual Review of Neuroscience·Nicholas Gaiano, Gord Fishell
May 29, 2004·The EMBO Journal·Rachel L Griffiths, Alicia Hidalgo
Feb 1, 2005·Developmental Biology·Bradley W Jones
Aug 22, 2006·Nature Reviews. Molecular Cell Biology·Sarah J Bray
Mar 18, 2008·Developmental Cell·Sarah K BowmanJuergen A Knoblich
Dec 19, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Takeshi AwasakiTzumin Lee
Apr 17, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Johnna DohertyMarc R Freeman
May 19, 2009·Current Opinion in Neurobiology·Irene Miguel-Aliaga, Stefan Thor
Jun 16, 2009·Nature Neuroscience·Hung-Hsiang YuTzumin Lee
Jun 27, 2009·Annual Review of Neuroscience·Arnold Kriegstein, Arturo Alvarez-Buylla
Dec 17, 2009·Neural Development·Natalya IzerginaHeinrich Reichert
Jan 30, 2010·Progress in Neurobiology·Tara N Edwards, Ian A Meinertzhagen
Jul 27, 2010·Current Opinion in Neurobiology·Ye Zhang, Ben A Barres
Aug 11, 2010·Genetics·Barret D PfeifferGerald M Rubin
Oct 29, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stephanie M StaceyDonald J van Meyel
Nov 12, 2010·Nature·David H Rowitch, Arnold R Kriegstein
Mar 9, 2011·Neuron·Tarran PierfeliceNicholas Gaiano
Apr 5, 2011·Nature Methods·Jian-Quan NiNorbert Perrimon
Aug 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·Aljoscha NernGerald M Rubin
Nov 10, 2011·Development·B V V G Reddy, Kenneth D Irvine
Dec 24, 2011·Cold Spring Harbor Protocols·Tobias StorkMarc R Freeman
Apr 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sanjay MagaviCarlos Lois
May 24, 2012·Cerebral Cortex·Jorge García-Marqués, Laura López-Mascaraque
Jun 30, 2012·Science·Hui-Hsin TsaiDavid H Rowitch
Oct 16, 2012·Cell Reports·Arnim JenettChristopher T Zugates
Jun 21, 2013·Nature·Omer Ali Bayraktar, Chris Q Doe

❮ Previous
Next ❯

Citations

Feb 26, 2020·Developmental Neurobiology·Jonas BitternChristian Klämbt
Nov 30, 2020·Progress in Neurobiology·Jorge Garcia-MarquesTzumin Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Astrocytes in Repair & Regeneration

Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.