Lineage Plasticity in Cancer Progression and Treatment

Annual Review of Cancer Biology
Clémentine Le MagnenCory Abate-Shen

Abstract

Historically, it has been widely presumed that differentiated cells are determined during development and become irreversibly committed to their designated fates. In certain circumstances, however, differentiated cells can display plasticity by changing their identity, either by dedifferentiation to a progenitor-like state or by transdifferentiation to an alternative differentiated cell type. Such cellular plasticity can be triggered by physiological or oncogenic stress, or it can be experimentally induced through cellular reprogramming. Notably, physiological stresses that promote plasticity, such as severe tissue damage, inflammation, or senescence, also represent hallmarks of cancer. Furthermore, key drivers of cellular plasticity include major oncogenic and tumor suppressor pathways and can be exacerbated by drug treatment. Thus, plasticity may help cancer cells evade detection and treatment. We propose that cancer can be considered as a disease of excess plasticity, a notion that has important implications for intervention and treatment.

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Citations

Sep 30, 2018·Disease Models & Mechanisms·Clémentine Le MagnenCory Abate-Shen
Jul 7, 2020·The Prostate·Joël R Federer-GsponerClémentine Le Magnen
Sep 9, 2020·Clinical and Translational Medicine·Jia-Hao LuFu-Bing Wang
Jun 2, 2020·Frontiers in Molecular Biosciences·Jean Paul Vernot
Oct 23, 2019·Disease Markers·Chiara NicolazzoPaola Gazzaniga
Jan 19, 2020·Nature Communications·Yota YasumizuDonald Kufe
Sep 6, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Nikolaos D KarakousisGeorge Papatheodoridis
Feb 2, 2021·Frontiers in Cell and Developmental Biology·Nikolas James TsiouplisAgeliki Tsagaratou
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Jul 25, 2021·Cancers·Archana P ThankamonyRadhika Nair
Aug 5, 2021·ELife·Mitchell S von ItzsteinJohn D Minna
Aug 12, 2020·Cancer Cell·Benjamin J Drapkin, John D Minna

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Methods Mentioned

BETA
single-cell sequencing
environmental stresses

Software Mentioned

Brainbow

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