Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites

Genome Biology
Tobias J SargeantAlan F Cowman

Abstract

The apicomplexan parasite Plasmodium falciparum causes the most severe form of malaria in humans. After invasion into erythrocytes, asexual parasite stages drastically alter their host cell and export remodeling and virulence proteins. Previously, we have reported identification and functional analysis of a short motif necessary for export of proteins out of the parasite and into the red blood cell. We have developed software for the prediction of exported proteins in the genus Plasmodium, and identified exported proteins conserved between malaria parasites infecting rodents and the two major causes of human malaria, P. falciparum and P. vivax. This conserved 'exportome' is confined to a few subtelomeric chromosomal regions in P. falciparum and the synteny of these and surrounding regions is conserved in P. vivax. We have identified a novel gene family PHIST (for Plasmodium helical interspersed subtelomeric family) that shares a unique domain with 72 paralogs in P. falciparum and 39 in P. vivax; however, there is only one member in each of the three species studied from the P. berghei lineage. These data suggest radiation of genes encoding remodeling and virulence factors from a small number of loci in a common Plasmodium ances...Continue Reading

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Software Mentioned

GCRMA
Phobius
hmmer
NoSS
MUSCLE
affy
ExportPred
PHISTc
PUZZLE
PlasmoDB

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