Lineage specification in the early mouse embryo

Experimental Cell Research
Fredrik Lanner

Abstract

Before the mammalian embryo is ready to implant in the uterine wall, the single cell zygote must divide and differentiate into three distinct tissues; trophectoderm (prospective placenta), primitive endoderm (prospective yolk sac), and pluripotent epiblast cells which will form the embryo proper. In this review I will discuss our current understanding of how positional information, cell polarization, signaling pathways, and transcription factor networks converge to drive and regulate the progressive segregation of the first three cell types in the mouse embryo.

References

Jan 13, 1995·Science·B FeldmanM Goldfarb
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·E ArmanP Lonai
Apr 9, 2002·Genes & Development·Junji FujikuraHitoshi Niwa
Jan 7, 2003·Genes & Development·Ariel A AvilionRobin Lovell-Badge
May 16, 2003·Genesis : the Journal of Genetics and Development·Sarah N Goldin, Virginia E Papaioannou
Jan 20, 2005·Journal of Cell Science·Berenika PlusaMagdalena Zernicka-Goetz
Dec 13, 2005·Nature Reviews. Molecular Cell Biology·Magdalena Zernicka-Goetz
Jun 15, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yojiro YamanakaJanet Rossant
Nov 6, 2007·Development·Jens-Erik Dietrich, Takashi Hiiragi
Dec 18, 2007·Mechanisms of Development·Noriyuki NishiokaHiroshi Sasaki
Aug 30, 2008·Development·Berenika PlusaAnna-Katerina Hadjantonakis
Sep 26, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Kathy Q CaiXiang-Xi Xu
May 9, 2009·Developmental Biology·Sigolène M MeilhacMagdalena Zernicka-Goetz
Mar 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Samantha A MorrisMagdalena Zernicka-Goetz
May 4, 2010·Developmental Biology·Daniel M Messerschmidt, Rolf Kemler
Nov 26, 2010·PloS One·Maria KeramariSusan J Kimber
Jan 25, 2011·Nature Cell Biology·Nicolas PlachtaPeriklis Pantazis
Dec 17, 2011·Developmental Cell·Stephen FrankenbergClaire Chazaud
Mar 17, 2012·Developmental Cell·Cong XuLeonard I Zon
Apr 25, 2012·Proceedings of the National Academy of Sciences of the United States of America·Pratik HomeSoumen Paul
Sep 21, 2012·Development·Stephanie BlijAmy Ralston
Nov 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Yoshikazu HirateHiroshi Sasaki

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Citations

Dec 15, 2015·Development, Growth & Differentiation·Kouji Komatsu, Toshihiko Fujimori
Sep 16, 2015·The Journal of Nutritional Biochemistry·Mari KudoShinichi Kume
Nov 1, 2017·Biology of Reproduction·Hannah M WearKaren H Watanabe
May 10, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Li TangWenming Xu
Jun 27, 2017·NPJ Systems Biology and Applications·Alen TosenbergerGeneviève Dupont
Aug 29, 2019·Iranian Journal of Biotechnology·Forough MahdavinezhadMojtaba Dashtizad
Oct 7, 2020·International Journal of Molecular Sciences·Jong-Nam OhChang-Kyu Lee
Jan 16, 2015·Journal of Cell Science·Dayana KrawchukYojiro Yamanaka
Mar 6, 2016·Genes & Development·Nathan P YoungReuben J Shaw

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