Linear accelerator radiosurgery for treatment of vestibular schwannomas in neurofibromatosis 2

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Y-H KuoB P Brophy

Abstract

Management of vestibular schwannomas in patients with neurofibromatosis 2 (NF2) balances growth control against preservation of hearing with the primary aim of maintaining patient quality of life. Surgical resection of these lesions carries greater risk of functional deterioration than in sporadic cases. Stereotactic radiosurgery is a less invasive option that provides comparable, if not superior outcomes to resection. Previous studies on the efficacy of stereotactic radiosurgery for vestibular schwannomas in NF2 have reported results from delivery by Gamma Knife systems. The efficacy of linear accelerator (LINAC) delivered treatment has not been specifically addressed. Modelling studies suggest that lesional conformality is superior with Gamma Knife, but clinical studies on sporadic vestibular schwannomas show equivalent results between the two systems. Our experience with LINAC radiosurgery in NF2 reported here shows good long-term growth control in four patients with vestibular schwannomas.

References

Jul 1, 1995·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·S CharabiM Tos
Mar 1, 1993·Journal of Neuropathology and Experimental Neurology·R A Sobel
Feb 13, 2002·Journal of Neurosurgery·Victor-Felix MautnerLan Kluwe
Sep 10, 2003·Journal of Neurosurgery·Goro OtsukaJun Yoshida
Mar 17, 2004·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Ann MasudaUNKNOWN Natural History Consortium
Sep 9, 2005·British Journal of Neurosurgery·D G R EvansR Ramsden
Feb 9, 2006·International Journal of Radiation Oncology, Biology, Physics·Stephanie E CombsDaniela Schulz-Ertner
Nov 24, 2006·Journal of Neurosurgery·William A FriedmanFrank J Bova

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Citations

Aug 28, 2012·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·G NoëlZ Jastaniah
Jul 12, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Daniel E RoosAndrew C Zacest
Aug 7, 2021·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Peter L Santa MariaIris C Gibbs

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