We investigated the relationship between neuronal activity, oxygen metabolism, and hemodynamic responses in rat somatosensory cortex with simultaneous optical intrinsic signal imaging and spectroscopy, laser Doppler flowmetry, and local field potential recordings. Changes in cerebral oxygen consumption increased linearly with synaptic activity but with a threshold effect consistent with the existence of a tissue oxygen buffer. Modeling analysis demonstrated that the coupling between neuronal activity and hemodynamic response magnitude may appear linear over a narrow range but incorporates nonlinear effects that are better described by a threshold or power law relationship. These results indicate that caution is required in the interpretation of perfusion-based indicators of brain activity, such as functional magnetic resonance imaging (fMRI), and may help to refine quantitative models of neurovascular coupling.
Effect of alpha-chloralose, halothane, pentobarbital and nitrous oxide anesthesia on metabolic coupling in somatosensory cortex of rat
Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging
Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects
BOLD based functional MRI at 4 Tesla includes a capillary bed contribution: echo-planar imaging correlates with previous optical imaging using intrinsic signals
Interactions between electrical activity and cortical microcirculation revealed by imaging spectroscopy: implications for functional brain mapping
A model for the coupling between cerebral blood flow and oxygen metabolism during neural stimulation
Vascular imprints of neuronal activity: relationships between the dynamics of cortical blood flow, oxygenation, and volume changes following sensory stimulation
Modification of activity-dependent increases of cerebral blood flow by excitatory synaptic activity and spikes in rat cerebellar cortex
Increased cortical oxidative metabolism due to sensory stimulation: implications for functional brain imaging
Early temporal characteristics of cerebral blood flow and deoxyhemoglobin changes during somatosensory stimulation
Spatiotemporal dynamics of the BOLD fMRI signals: toward mapping submillimeter cortical columns using the early negative response
Spectroscopic analysis of neural activity in brain: increased oxygen consumption following activation of barrel cortex
Increased oxygen consumption following activation of brain: theoretical footnotes using spectroscopic data from barrel cortex
No evidence for early decrease in blood oxygenation in rat whisker cortex in response to functional activation
Concurrent optical imaging spectroscopy and laser-Doppler flowmetry: the relationship between blood flow, oxygenation, and volume in rodent barrel cortex
Coupling and uncoupling of activity-dependent increases of neuronal activity and blood flow in rat somatosensory cortex
Neuronal activity-induced changes of local cerebral microvascular blood oxygenation in the rat: effect of systemic hyperoxia or hypoxia
Coupling of total hemoglobin concentration, oxygenation, and neural activity in rat somatosensory cortex
Evaluation of coupling between optical intrinsic signals and neuronal activity in rat somatosensory cortex
Columnar specificity of microvascular oxygenation and volume responses: implications for functional brain mapping
Assessment of brain interactivity in the motor cortex from the concept of functional connectivity and spectral analysis of fMRI data
Brain cortical mapping by simultaneous recording of functional near infrared spectroscopy and electroencephalograms from the whole brain during right median nerve stimulation.
Percept-related activity in the human somatosensory system: functional magnetic resonance imaging studies
Functional representation of the finger and face in the human somatosensory cortex: intraoperative intrinsic optical imaging
Spatial extent of oxygen metabolism and hemodynamic changes during functional activation of the rat somatosensory cortex
Sensory inputs from whisking movements modify cortical whisker maps visualized with functional magnetic resonance imaging.
Dynamic neurovascular coupling and uncoupling during ictal onset, propagation, and termination revealed by simultaneous in vivo optical imaging of neural activity and local blood volume.
Neurovascular coupling and epilepsy: hemodynamic markers for localizing and predicting seizure onset
Multispectral reflectance imaging of brain activation in rodents: methodological study of the differential path length estimations and first in vivo recordings in the rat olfactory bulb
Fine detail of neurovascular coupling revealed by spatiotemporal analysis of the hemodynamic response to single whisker stimulation in rat barrel cortex.
Hemodynamic surrogates for excitatory membrane potential change during interictal epileptiform events in rat neocortex.
Separation of fNIRS signals into functional and systemic components based on differences in hemodynamic modalities
Comparisons of the dynamics of local field potential and multiunit activity signals in macaque visual cortex
Hypocapnia induced by involuntary hyperventilation during mental arithmetic reduces cerebral blood flow velocity
Using an achiasmic human visual system to quantify the relationship between the fMRI BOLD signal and neural response
Inverted optical intrinsic response accompanied by decreased cerebral blood flow are related to both neuronal inhibition and excitation
Activity-induced tissue oxygenation changes in rat cerebellar cortex: interplay of postsynaptic activation and blood flow
Neurometabolic coupling differs for suppression within and beyond the classical receptive field in visual cortex.
Depth-resolved imaging of functional activation in the rat cerebral cortex using optical coherence tomography
The relationship of resting cerebral blood flow and brain activation during a social cognition task in adolescents with chronic moderate to severe traumatic brain injury: a preliminary investigation.
Hemodynamic changes preceding the interictal EEG spike in patients with focal epilepsy investigated using simultaneous EEG-fMRI
Spatiotemporal evolution of functional hemodynamic changes and their relationship to neuronal activity
Pathway-specific variations in neurovascular and neurometabolic coupling in rat primary somatosensory cortex
BOLD consistently matches electrophysiology in human sensorimotor cortex at increasing movement rates: a combined 7T fMRI and ECoG study on neurovascular coupling
Optical coherence tomography (OCT) reveals depth-resolved dynamics during functional brain activation.
Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.
Brain developing: Influences & Outcomes
This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.