PMID: 9183486May 1, 1997Paper

Linear growth in early treated children with congenital hypothyroidism

Acta Paediatrica
S HeyerdahlA Larsson

Abstract

Length/height was studied from birth to 6 years of age in 103 children with congenital hypothyroidism identified by the Norwegian or Swedish screening programs. We used the "infancy-childhood-puberty (ICP) growth model". This model describes normal linear growth during the first 3 years of life by an infancy component with the addition of a childhood component, the latter acting from the second half of the first year. In comparison with reference children, children with hypothyroidism had reduced growth from 6 to 12 months, and increased growth after 12 months of age. Mean onset of the childhood component of growth was delayed from 8.1 months (SD 1.9) to 10.4 months (SD 2.2) in girls, and from 8.9 months (SD 2.0) to 11.0 months (SD 2.1) in boys. Age at onset of the childhood component was correlated with age at start of treatment (r = 0.24), and in children with more severe hypothyroidism (pretreatment serum thyroxine < 40 nmol/l) inversely correlated with the L-thyroxine dose at start of treatment (r = -0.40). Change in height standard deviation score from 1 to 3 years of age was correlated with the serum thyroxine concentration at age 1 year (r = 0.30). The delay in the onset of the childhood component of growth and the assoc...Continue Reading

References

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Citations

Feb 13, 2002·Thyroid : Official Journal of the American Thyroid Association·Mariacarolina SalernoAlfred Tenore
Feb 26, 1999·Thyroid : Official Journal of the American Thyroid Association·G Van Vliet
Jan 8, 2004·Archives of Disease in Childhood·S C ConradB L Silverman
Sep 7, 2012·Case Reports in Endocrinology·Rita Ann KubickyFrancesco De Luca
Jul 19, 2016·Advances in Pediatrics·Janiel PimentelChirag Kapadia
Feb 20, 2018·Indian Journal of Pediatrics·Meena P Desai, Vijayalakshmi Bhatia
Jan 5, 2002·Journal of Developmental and Behavioral Pediatrics : JDBP·S I SongJ Rovet

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