Linear IgA bullous dermatosis after contact with sodium hypochlorite

Dermatology : International Journal for Clinical and Investigative Dermatology
R PellicanoC De Simone

Abstract

The onset of linear IgA bullous dermatosis (LABD) is generally spontaneous, but a number of cases of LABD have been reported either following drug exposure or in association with malignancies. We describe a patient who developed a vesicular eruption shortly after an irritant dermatitis caused by the contact with a detergent containing sodium hypochlorite. Direct immunofluorescence revealed linear deposits of IgA and C3 in the epidermal basement membrane. The patient's serum contained IgA that immunoblotted a 180-kD polypeptide in extracts of human keratinocytes. The patient responded promptly to therapy with dapsone. We suggest a possible pathogenetic relationship between the chemical dermatitis and LABD in this patient.

Citations

Dec 3, 1999·International Journal of Dermatology·C A Egan, J J Zone
Sep 20, 2000·Mayo Clinic Proceedings·M B BouldinM D Davis
Oct 16, 2004·Journal of the European Academy of Dermatology and Venereology : JEADV·T SchultewolterJ Dissemond
Dec 20, 2005·The Journal of Dermatology·Hanae OnoderaToshihide Akasaka
Jun 4, 2014·The British Journal of Dermatology·K WozniakC Kowalewski
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Jan 29, 2019·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Robin J SlaughterLeo J Schep
May 28, 2019·Orphanet Journal of Rare Diseases·Giovanni GenoveseAngelo Valerio Marzano

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