PMID: 15244240Jul 13, 2004Paper

Linear IgA bullous dermatosis of neonatal onset: case report and review of the literature

Acta Paediatrica
Y KishidaK Baba

Abstract

Several small blisters were noticed on the forehead and the trunk of a newborn boy on day 1. The blisters gradually enlarged and spread over the whole body including the oral mucosa. A skin biopsy was performed twice and subepidermal bullae with polymorphonuclear and mononuclear cell infiltration were demonstrated. Direct immunofluorescence showed linear IgA, IgG and C3 depositions along the basement membrane zone and this finding led to a diagnosis of linear IgA bullous dermatosis. So far, internationally, only one case has ever been reported on the disease at neonatal onset. The skin lesions spontaneously regressed and the mucosal lesions were controlled with diaminodiphenylsulfone. In neonates with prolonged blistering, autoimmune disease such as linear IgA bullous dermatosis should be considered within the differential diagnosis and an immunofluorescence study must be performed.

References

Sep 1, 1987·The British Journal of Dermatology·B BhogalP H McKee
Mar 1, 1982·Journal of the American Academy of Dermatology·J H Schiffner
Jun 1, 1993·Pediatric Dermatology·L L HruzaG B Mallory

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Citations

May 9, 2012·Immunology and Allergy Clinics of North America·Vanessa A Venning
May 25, 2011·Dermatologic Clinics·Vanessa A Venning
May 25, 2011·Dermatologic Clinics·Emily M Mintz, Kimberly D Morel
Apr 20, 2010·Journal of the American Academy of Dermatology·Charissa Mia D Salud, Marie Eleanore O Nicolas
Dec 22, 2015·Clinics in Dermatology·Kalyani MaratheKimberly D Morel
Mar 3, 2009·Pediatric Dermatology·Nesrine KenaniRafia Nouira
Sep 13, 2011·Pediatric Dermatology·Meena R JulapalliDenise W Metry
May 8, 2015·Journal of Cutaneous Pathology·Ami SaraiyaGladys Telang
Apr 19, 2016·Pediatric Dermatology·Cathy Y ZhaoDedee F Murrell
Jan 13, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·A DiociaiutiM El Hachem
Mar 6, 2018·Journal of Cutaneous Medicine and Surgery·Matthew T MazurekYousef Etoom
Oct 2, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·L GiraudS Hadj-Rabia
Jul 9, 2016·Current Opinion in Pediatrics·Cathy Y Zhao, Dedee F Murrell

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