Linear IgA disease: successful application of immunoadsorption and review of the literature

Dermatology : International Journal for Clinical and Investigative Dermatology
Michael KasperkiewiczEnno Schmidt

Abstract

Linear IgA disease (LAD) is an autoimmune subepidermal blistering disorder characterized by IgA autoantibodies at the dermal-epidermal junction. Conventional first-line treatments include dapsone with or without oral glucocorticosteroids. Various other therapeutic approaches have been used in refractory patients. Immunoadsorption (IA) has been previously successfully applied in severe and/or otherwise treatment-resistant IgG-mediated immunobullous disorders. Here, we report a patient with a severe generalized LAD in whom adjuvant tryptophan IA was associated with rapid healing of skin lesions. Our observation suggests that IA may also be a helpful adjuvant treatment option for severe LAD.

Citations

May 17, 2013·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M Sárdy, M Kasperkiewicz
Jun 9, 2012·Dermatology : International Journal for Clinical and Investigative Dermatology·P A MüllerS Benoit
Dec 6, 2011·Clinics in Dermatology·Giulio Fortuna, M Peter Marinkovich
Dec 6, 2011·Clinics in Dermatology·Donna A Culton, Luis A Diaz
Oct 22, 2011·Clinics in Dermatology·Carol E Cheng, Daniela Kroshinsky
Sep 20, 2011·Dermatologic Clinics·Sue Yin Ng, Vanessa V Venning
Sep 20, 2011·Dermatologic Clinics·Emily M Mintz, Kimberly D Morel
Sep 20, 2011·Autoimmunity·Michael KasperkiewiczEnno Schmidt
Nov 20, 2018·Frontiers in Medicine·Mareike WitteEnno Schmidt
Dec 7, 2018·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·Franziska HübnerEnno Schmidt
Mar 9, 2021·Journal of the American Academy of Dermatology·Carmen M MontagnonStanislav N Tolkachjov
Apr 8, 2021·Deutsches Ärzteblatt International·Nina van BeekEnno Schmidt
Aug 10, 2021·Deutsches Ärzteblatt International·Nina van BeekEnno Schmidt

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