Linear modelling analysis of baroreflex control of arterial pressure variability in rats

The Journal of Physiology
Bruno ChapuisClaude Julien

Abstract

The objective of the present study was to examine whether a simple linear feedback model of arterial pressure (AP) control by the sympathetic nervous system would be able to reproduce the characteristic features of normal AP variability by using AP and renal sympathetic nerve activity (RSNA) data collected in conscious sinoaortic baroreceptor denervated (SAD) rats. As compared with baroreceptor-intact rats (n=8), SAD rats (n=10) had increased spectral power (+ 680%) of AP in the low frequency range (LF, 0.0003-0.14 Hz) and reduced power (-19%) in the mid-frequency range (MF, 0.14-0.8 Hz) containing Mayer waves. In individual SAD rats, RSNA data were translated into 'sympathetic' AP time series by using the RSNA-AP transfer function that had been previously characterized in anaesthetized rats. AP 'perturbation' time series were then calculated by subtracting 'sympathetic' from actual AP time series. Actual RSNA and AP 'perturbation' time series were introduced in a reflex loop that was closed by using the previously identified baroreflex transfer function (from baroreceptor afferent activity to RSNA). By progressively increasing the open-loop static gain, it was possible to compute virtual AP power spectra that increasingly devi...Continue Reading

References

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Citations

Jan 28, 2012·Current Atherosclerosis Reports·Bernard M Y Cheung, Chao Li
Mar 21, 2002·Clinical and Experimental Pharmacology & Physiology·C BarrèsC Julien
Mar 28, 2009·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Nicola MontanoClaude Julien
Mar 1, 2008·Clinical and Experimental Pharmacology & Physiology·Claude Julien
Oct 18, 2005·Acta Pharmacologica Sinica·Claude Julien
Oct 3, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Robert J BrychtaAndré Diedrich
Nov 11, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Jennifer A NowakJulian M Stewart
Jul 18, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·He-Hui XieDing-Feng Su
Mar 19, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bernard CohenSergei B Yakushin
Apr 26, 2011·Journal of Neuroscience Methods·Clément GalletClaude Julien
Sep 29, 2009·Autonomic Neuroscience : Basic & Clinical·Bruno ChapuisClaude Julien
Jul 24, 2007·Medical Image Analysis·J Cohen-AdadF Lesage
Jan 12, 2017·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R AiresJ G Mill
May 14, 2008·Journal of Hypertension·Claude JulienGianfranco Parati
Dec 4, 2008·Journal of Hypertension·Claude Julien
Jan 7, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Patrick Osei-Owusu, Karie Scrogin
Apr 27, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Feng LiMaureen Keller-Wood
Jun 8, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Adrian GerickeAndreas Patzak
Sep 7, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roy KanbarClaude Julien
Apr 27, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Chiara BerteottiAlessandro Silvani
Mar 3, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Harald M StaussDon D Sheriff
Sep 16, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roy KanbarClaude Julien
Mar 4, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Léa EmonnotClaude Julien
Jun 4, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Delphine BertramClaude Julien
Jan 16, 2007·Journal of Applied Physiology·Gian Domenico Pinna

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