Linezolid and vancomycin, alone and in combination with rifampin, compared with moxifloxacin against a multidrug-resistant and a vancomycin-tolerant Streptococcus pneumoniae strain in an in vitro pharmacodynamic model.

Antimicrobial Agents and Chemotherapy
Raymond Cha, Michael J Rybak

Abstract

Potential alternatives, including linezolid, adjunctive rifampin, and moxifloxacin, were evaluated against vancomycin-tolerant (P9802-020) and vancomycin-susceptible clinical isolates of Streptococcus pneumoniae in an in vitro pharmacodynamic model. Vancomycin exhibited maximal killing of 2-log(10) CFU/ml against P9802-020. Linezolid, moxifloxacin, and linezolid plus rifampin exhibited 99.9% killing against both isolates. These alternatives should be considered for further evaluation against vancomycin-tolerant S. pneumoniae.

References

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Citations

Mar 12, 2004·International Journal of Antimicrobial Agents·Bülent Bozdogan, Peter C Appelbaum
Jan 24, 2007·Antimicrobial Agents and Chemotherapy·Lauren M BoakRoger L Nation
Jun 10, 2010·Clinical Pharmacokinetics·Antonello Di PaoloMario Del Tacca
Mar 2, 2011·Future Medicinal Chemistry·Pavan K VaddadyBernd Meibohm
May 12, 2009·Médecine et maladies infectieuses·P Chavanet

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