Linezolid extracorporeal removal during haemodialysis with high cut-off membrane in critically ill patients

International Journal of Antimicrobial Agents
Gianluca VillaChiara Adembri

Abstract

Continuous venovenous haemodialysis with high cut-off membrane (HCO-CVVHD) is often used in critically ill septic patients with acute kidney injury (AKI) to sustain renal function and to remove circulating inflammatory mediators. The aim of this study was to analyse the extracorporeal removal of linezolid and related alterations in pharmacokinetic/pharmacodynamic (PK/PD) parameters during HCO-CVVHD. Three critically ill septic patients with AKI, treated with linezolid and HCO-CVVHD, were prospectively observed. To calculate the extracorporeal clearance of linezolid and the PK parameters, effluent, pre-filter and post-filter samples were contemporaneously collected before linezolid infusion, just after 1-h infusion (maximum serum concentration; C(max)), at 3 h and 6 h after dosing, and before the next dose (trough serum concentration; C(min)). Linezolid C(max) and C(min) (pre-filter) ranged from 10.4-23.5 mg/L and from 2.9-10.3 mg/L. The dialysate saturation coefficient was 0.66-0.85 and the extracorporeal clearance with a diffusive dose of 35 m L/kg/h ranged from 2.1-2.5 L/h. Total linezolid clearance was between 1.7 L/h and 6.3 L/h. The total area under the plasma concentration-time curve (AUC0-∞) ranged from 95.1 mgh/L to 352...Continue Reading

References

Mar 20, 2004·Nature Reviews. Microbiology·George L Drusano
Dec 7, 2007·International Journal of Antimicrobial Agents·Chiara AdembriAndrea Novelli
Mar 19, 2013·Journal of Critical Care·Pablo Cardinal-FernándezJosé A Lorente
Jul 12, 2014·Critical Care : the Official Journal of the Critical Care Forum·Michael ZollerJohannes Zander
Dec 5, 2014·Blood Purification·Gianluca VillaClaudio Ronco

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Citations

Mar 17, 2016·Expert Opinion on Drug Metabolism & Toxicology·Dario CattaneoMichael Neely
May 22, 2019·Antimicrobial Agents and Chemotherapy·Valentina PistolesiEnrico Fiaccadori
Nov 20, 2016·Critical Care : the Official Journal of the Critical Care Forum·Gianluca VillaChiara Adembri
Nov 28, 2017·The International Journal of Artificial Organs·Zaccaria RicciClaudio Ronco

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