Linezolid-induced thrombocytopenia increases mortality risk in intensive care unit patients, a 10 year retrospective study

Journal of Clinical Pharmacy and Therapeutics
Hyung-Sook KimSandy Jeong Rhie

Abstract

Linezolid-induced thrombocytopenia is one of the many confounding conditions in critically ill patients. It is rare but prognostic importance of linezolid-induced thrombocytopenia in ICU population has not been well investigated. The study is to assess the incidence and risk factors of linezolid-induced thrombocytopenia in ICU patients. We conducted a retrospective study with ICU patients treated with linezolid between January 2005 and December 2015 at the adult medical, surgical, emergency, and neurological ICUs at 1500-bed tertiary university medical center. There were 60 patients (mean age: 69.8 ± 11.9), 29 (48.3%) who developed linezolid-induced thrombocytopenia determined by the Naranjo algorithm on a case-by-case basis during the study period. The patients with linezolid-induced thrombocytopenia had a higher rate of any malignancy (41.4% vs 9.7%, P = 0.007), elevated baseline creatinine levels (median [interquartile range; IQR]: 1.7 mg/dL [0.9-2.5] vs 0.9 mg/dL [0.6-1.3]; P = 0.042), and lower baseline platelet counts (median [IQR] 160 × 109 /L [128-230] vs 194 × 109 /L [118-285]; P = 0.296) than patients without linezolid-induced thrombocytopenia. The patients who developed thrombocytopenia received more platelet transfu...Continue Reading

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Citations

Jul 15, 2020·Antibiotics·Iris H Chen, David P Nicolau
Feb 21, 2021·Journal of Pharmaceutical Sciences·Saki TakahashiHideto To
Aug 19, 2021·Infection & chemotherapy·Wichai SantimaleeworagunSudaluck Thunyaharn
Nov 4, 2021·International Journal of Clinical Pharmacy·Xiaonian HanXiaojing Nie

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