Lingual fibrosarcoma induced by 7, 12-dimethylbenzanthracene in the rat

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
C PerrinH Joyeux

Abstract

A single injection of 5 mg of 7, 12-dimethylbenzanthracene (DMBA) resulted in a high incidence of lingual fibrosarcoma in 67 Wistar rats. No metastases were found. We studied the influence of age and sex on the incidence, latency of tumors, loss of weight and the spontaneous survival of animals. The method described offers an experimental model for the study of cachexia resulting from upper digestive and respiratory tract cancer.

References

Oct 1, 1977·Oral Surgery, Oral Medicine, and Oral Pathology·P Marefat, G Shklar
Oct 1, 1977·Oral Surgery, Oral Medicine, and Oral Pathology·J W Eveson, D G MacDonald
Mar 1, 1971·British Journal of Cancer·A Glucksmann, C P Cherry
May 1, 1984·Oral Surgery, Oral Medicine, and Oral Pathology·N E Steidler, P C Reade
Jun 1, 1981·Journal of Oral Pathology·J W Eveson

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Citations

Jul 28, 2020·International Journal of Molecular Sciences·Sara Peixoto da SilvaRui Medeiros

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