PMID: 8606473Feb 21, 1996Paper

Linguistic ability in early life and cognitive function and Alzheimer's disease in late life. Findings from the Nun Study

JAMA : the Journal of the American Medical Association
D A SnowdonW R Markesbery

Abstract

To determine if linguistic ability in early life is associated with cognitive function and Alzheimer's disease in late life. Two measures of linguistic ability in early life, idea density and grammatical complexity, were derived from autobiographies written at a mean age of 22 years. Approximately 58 years later, the women who wrote these autobiographies participated in an assessment of cognitive function, and those who subsequently died were evaluated neuropathologically. Convents in the United States participating in the Nun Study; primarily convents in the Milwaukee, Wis, area. Cognitive function was investigated in 93 participants who were aged 75 to 95 years at the time of their assessments, and Alzheimer's disease was investigated in the 14 participants who died at 79 to 96 years of age. Seven neuropsychological tests and neuropathologically confirmed Alzheimer's disease. Low idea density and low grammatical complexity in autobiographies written in early life were associated with low cognitive test scores in late life. Low idea density in early life had stronger and more consistent associations with poor cognitive function than did low grammatical complexity. Among the 14 sisters who died, neuropathologically confirmed Al...Continue Reading

Citations

Apr 13, 2002·Neuropsychology·Raja ParasuramanTrey Sunderland
Nov 26, 2013·Brain : a Journal of Neurology·Janna H NeltnerPeter T Nelson
Mar 1, 2014·Demography·Nicole SchneeweisRudolf Winter-Ebmer
Oct 26, 2013·International Journal of Alzheimer's Disease·J OlazaránF Bermejo-Pareja
Mar 10, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·L LetenneurJ F Dartigues
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·R P FriedlandS M Debanne
Apr 6, 2001·BMJ : British Medical Journal·L J Whalley, I J Deary
Aug 21, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·C HelmerJ F Dartigues
Mar 18, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·J-M KimJ-S Yoon
Sep 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ottavio V VitoloMichael Shelanski
Dec 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Eric M ReimanJohn Hardy
Feb 6, 2004·BMJ : British Medical Journal·Marcus RichardsMichael E J Wadsworth
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Mark P MattsonZhihong Guo
Mar 5, 2005·The Journal of Neuropsychiatry and Clinical Neurosciences·Jane B TornatoreMary E McGann
Nov 25, 2005·Journal of Geriatric Psychiatry and Neurology·James A MortimerDavid A Snowdon
Feb 18, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·N ScarmeasY Stern
Sep 12, 2006·Journal of the International Neuropsychological Society : JINS·Elizabeth W TwamleyMark W Bondi
Feb 3, 2007·American Journal of Epidemiology·Sujuan GaoHugh C Hendrie
Apr 14, 2007·American Journal of Epidemiology·Suzanne L TyasRichard J Kryscio
Apr 17, 2007·Journal of Epidemiology and Community Health·Ian J Deary, G David Batty
Oct 2, 2007·Age and Ageing·Suzanne L TyasWilliam R Markesbery
Mar 5, 2008·Alzheimer Disease and Associated Disorders·Lissy JarvikAlan B Zonderman
May 24, 2008·International Psychogeriatrics·Constantine G LyketsosPeter P Zandi
Jun 5, 2008·Behavior Research Methods·Cati BrownMichael A Covington
Jul 10, 2008·PloS One·Michael J ValenzuelaHenry Brodaty
Jun 3, 2009·Alzheimer Disease and Associated Disorders·James A MortimerWilliam R Markesbery
Jul 4, 2009·BMJ : British Medical Journal·Krister HåkanssonMiia Kivipelto
Oct 24, 2009·Population Studies·Kathryn M YountAnn M Digirolamo
Feb 9, 2010·Journal of Dental Research·P S SteinM B Gibbs
Sep 15, 2010·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Michal EngelmanMichael J Klag
Aug 10, 2011·Archives of Neurology·Joshua A SonnenThomas J Montine
Nov 22, 2011·Acta Neuropathologica·Elliott J MufsonStephen W Scheff
Feb 11, 2012·Journal of the International Neuropsychological Society : JINS·Timothy S ChangMark A Sager
Feb 24, 2012·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Sarah Tomaszewski FariasBruce Reed
Jul 3, 2013·The British Journal of Psychiatry : the Journal of Mental Science·Tom C RussG David Batty
Oct 22, 2013·Brain : a Journal of Neurology·Samrah AhmedPeter Garrard
Sep 10, 2003·Experimental Aging Research·Tracy L Mitzner, Susan Kemper
Jan 14, 2004·Journal of Personality and Social Psychology·Ian J DearyHelen C Fox

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