Linguistic determinants of formal thought disorder in first episode psychosis.

Early Intervention in Psychiatry
Michael MackinleyLena Palaniyappan

Abstract

Thought disorder is a core feature of schizophrenia but assessment of disordered thinking is challenging, which may contribute to the paucity of mechanistic understanding of disorganization in early psychosis. We studied the use of linguistic connectives in relation to clinically quantified dimensions of thought disorder using automated speech analysis in untreated, first episode psychosis (FEPs) and healthy controls (HCs). 39 treatment-naïve, actively psychotic FEPs and 23 group matched HCs were recruited. Three one-minute speech samples were induced in response to photographs from the Thematic Apperception Test and speech was analysed using COH-METRIX software. Five connectives variables from the Coh-Metrix software were reduced using principle component analysis, resulting in two linguistic connectives factors. Thought disorder was assessed using the Thought Language Index (TLI) and the PANSS-8. Connective factors predicted disorganization, but not impoverishment suggesting aberrant use of connectives is specific to positive thought disorder. An independent t test comparing low and high disorganization FEPs showed higher load of acausal temporal connectives in high disorganization FEPs compared to low disorganization FEPs (m...Continue Reading

References

Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Jan 1, 1986·Schizophrenia Bulletin·N C Andreasen
Jan 1, 1986·Schizophrenia Bulletin·M R SolovayP S Holzman
Jan 1, 1994·Progress in Neuro-psychopharmacology & Biological Psychiatry·M J CuestaJ de Leon
Sep 2, 1998·Psychological Medicine·P D McGorryH J Jackson
Oct 3, 2002·The British Journal of Psychiatry : the Journal of Mental Science·Peter F LiddleRowena Weg
Sep 10, 2004·Behavior Research Methods, Instruments, & Computers : a Journal of the Psychonomic Society, Inc·Arthur C GraesserZhiqiang Cai
Feb 23, 2010·Schizophrenia Research·Iris E SommerMarco P M Boks
Oct 12, 2010·Language and Linguistics Compass·Gina R Kuperberg
May 13, 2014·European Child & Adolescent Psychiatry·Mart L J M EussenKirstin Greaves-Lord
Jan 1, 2015·NPJ Schizophrenia·Gillinder BediCheryl M Corcoran
Sep 19, 2016·Schizophrenia Research·Eric RocheMary Clarke
Feb 17, 2017·Schizophrenia Bulletin·Mara Hart, Richard R J Lewine
Jun 28, 2017·Human Brain Mapping·Tobias WensingThomas Nickl-Jockschat
Apr 22, 2018·The Lancet. Psychiatry·Tilo KircherJennifer Engelen
Jan 16, 2019·Early Intervention in Psychiatry·Matteo TonnaUNKNOWN GET UP Group

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Citations

May 8, 2021·European Archives of Psychiatry and Clinical Neuroscience·Tilo KircherArne Nagels
Sep 12, 2021·Seminars in Cell & Developmental Biology·Lena Palaniyappan

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