Link Between Celiac Disease and Inflammatory Bowel Disease

Journal of Clinical Gastroenterology
Ayesha ShahGerald J Holtmann

Abstract

The aim of this analysis was to assess in patients with inflammatory bowel disease (IBD) the risk of celiac disease and in celiac disease patients the risk of IBD. Previous studies report a possible association between IBD and celiac disease; however, this link is controversial. Using the search terms "inflammatory bowel disease" and "celiac disease," we identified initially 1525 publications. In total 27 studies met inclusion criteria. Proportions and 95% confidence intervals (CIs) for the prevalence of IBD in celiac disease and vice versa were compared with published prevalence rates for the respective geographic regions. We included 41,482 adult IBD patients (20,357 with Crohn's disease; 19,791 with ulcerative colitis; and 459 patients with celiac disease). Overall, in IBD patients the prevalence of celiac disease was 1110/100,000 (95% CI, 1010-1210/100,000) as compared with a prevalence of 620/100,000 (95% CI, 610-630/100,000) in the respective populations (odds ratio, 2.23; 95% CI, 1.99-2.50). In contrast, in patients with celiac disease, 2130/100,000 had IBD (95% CI, 1590-2670/100,000) as compared with 260/100,000 (95% CI, 250/100,000-270/100,000) in the respective populations (odds ratio, 11.10; 95% CI, 8.55-14.40). This...Continue Reading

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Citations

Sep 19, 2019·Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry·Humaira B NoorMd A T Sagor
Dec 13, 2019·Digestive Diseases and Sciences·John GubatanNielsen Q Fernandez-Becker
Jun 20, 2020·Molecular Nutrition & Food Research·Kimberly N Weaver, Hans Herfarth
Aug 23, 2019·World Journal of Gastroenterology : WJG·Jun-Hwan Yoo, Mark Donowitz
Jan 17, 2021·Inflammatory Bowel Diseases·Matteo BramuzzoPatrizia Alvisi
Feb 25, 2021·Digestive Diseases and Sciences·Marilia L MontenegroYan Bi
Mar 26, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Xiaoying KangKarin Wirdefeldt
May 19, 2021·Inflammatory Bowel Diseases·Motasem AlkhayyatMiguel Regueiro
Jun 3, 2021·Nutrients·Giacomo CaioGiorgio Zoli
Mar 30, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Emily W LopesHamed Khalili

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Software Mentioned

Comprehensive Meta - Analysis ( CMS )
OvidSP
Statistical Package for Social Sciences ( SPSS

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