Link between chemerin, central obesity, and parameters of the Metabolic Syndrome: findings from a longitudinal study in obese children participating in a lifestyle intervention

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Petra NiklowitzThomas Reinehr

Abstract

Chemerin has been suggested as a potential link between obesity and associated comorbidities in humans. Therefore, we studied the relationships between chemerin, parameters of fat mass, and Metabolic Syndrome (MetS) in obese children before and after weight reduction. We determined chemerin, bioactive leptin (bioLep), BMI-SDS, waist circumference (WC), body fat based on skinfold measurements and bioimpedance analyses, lipids, transaminases, insulin resistance index HOMA, and blood pressure in 88 obese children participating in a lifestyle intervention at baseline and 1 year later. Furthermore, we determined chemerin concentrations in 23 normal-weight children. Obese children demonstrated significantly (p < 0.001) higher chemerin concentrations compared to normal-weight children (96.2 ± 23.0 versus 63.1 ± 12.4 ng/ml). The chemerin concentrations were not related to age or gender. Prepubertal children had higher (p = 0.024) chemerin concentrations than pubertal children (71.0 ± 13.4 versus 58.0 ± 8.9 ng/ml). Weight loss was associated with a decrease of chemerin (-14.0 ± 22.0 ng/ml; p < 0.001) and an improvement of all parameters of the MetS. Chemerin was significantly related to BMI-SDS, WC, and bioLep in cross-sectional and lon...Continue Reading

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Citations

Oct 20, 2018·Current Diabetes Reports·Thomas Reinehr, Christian Ludwig Roth
Jul 18, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiaoxue LiYun Sun
Jun 21, 2019·Clinical Medicine Insights. Pediatrics·Hong-Jun BaHong-Shan Chen
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Jan 23, 2021·Journal of Physiology and Biochemistry·Fermin I Milagro, Christian Carpéné
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Apr 10, 2021·European Journal of Pediatrics·Mariana De Santis FilgueirasJuliana Farias de Novaes
May 7, 2020·Protein and Peptide Letters·Sara ParrettiniGiovanni Luca

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Methods Mentioned

BETA
ELISA
biopsy
biopsies

Software Mentioned

Winstat®

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