Link between estrogen deficiency osteoporosis and susceptibility to bone metastases: A way towards precision medicine in cancer patients

The Breast : Official Journal of the European Society of Mastology
F SalamannaM Fini

Abstract

Different fields of cancer management consider bone health to be of increasing clinical importance for patients: 1) presence of bone metastases in many solid tumors, 2) use of bone-targeted treatments in the reduction of bone metastasis, 3) effects of cancer treatment on reproductive hormones, critical for normal bone remodeling maintenance. Additionally, bone microenvironment is further complicated by the decline of ovarian sex steroid production and by the related increase in inflammatory factors linked to menopause, which result in accelerated bone loss and increased risk of osteoporosis (OP). Similarly, cancers and metastasis to bone showed a close relationship with sex hormones (particularly estrogen). Thus, these findings raise a question: Could pre-existing estrogen deficiency OP promote and/or influence cancer cell homing and tumor growth in bone? Although some preclinical and clinical evidence exists, it is mandatory to understand this aspect that would be relevant in the clinical theatre, where physicians need to understand the treatments available to reduce the risk of skeletal disease in cancer patients. This descriptive systematic review summarizes preclinical and clinical studies dealing with bimodal interactions ...Continue Reading

Citations

May 31, 2019·Cellular and Molecular Life Sciences : CMLS·Daniele BellaviaG Giavaresi
Sep 10, 2019·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Scott O Lilienfeld
Mar 3, 2019·Cancer Metastasis Reviews·Sofia AvnetNicola Baldini
Mar 15, 2019·Journal of Experimental & Clinical Cancer Research : CR·Claudia ChiodoniKatia Scotlandi

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