Linkage analysis of HSP70 genes and historecognition locus in botryllus schlosseri

Immunogenetics
M B Fagan, I L Weissman

Abstract

The protochordate allorecognition system has long invited comparison with the vertebrate major histocompatibility complex (MHC). In the colonial species Botryllus schlosseri, a rapid fusion or rejection response resembling graft acceptance or rejection in vertebrates is controlled by a single highly polymorphic genetic region. Because linkage between heat shock protein 70 (HSP70) genes and the MHC appears to be conserved within the vertebrate lineage, linkage relationships between two HSP70 genes (HSP70.1 and HSP70.2) and the historecognition locus (FuHC) have been analyzed in B. schlosseri. Segregation patterns of restriction fragment length polymorphisms located in the 3' flanking regions of HSP70.1 and HSP70.2 were determined for progeny of defined crosses. These progeny were also analyzed for fusibility type by an in vivo cut colony assay. No close linkage was detected between any of the three loci. These results do not support the hypothesis that the allorecognition response in B. schlosseri is determined by an MHC homologue. However, it remains a possibility that orthologues of other MHC-linked genes will be linked to the B. schlosseri FuHC.

Citations

Dec 18, 2004·Immunogenetics·James KelleyJohn Trowsdale
Apr 15, 2004·Immunology Letters·Louis Du Pasquier
Feb 15, 2001·Journal of Hematotherapy & Stem Cell Research·S Agrawal, M C Kishore
May 13, 1999·Immunological Reviews·B G MagorI L Weissman
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·D J LairdI L Weissman
Jun 18, 2004·Immunological Reviews·Baruch Rinkevich
Jun 18, 2004·Immunological Reviews·Louis Du PasquierRosaria De Santis
Jul 11, 2013·ELife·Ayelet VoskoboynikStephen R Quake
Sep 13, 2003·Immunological Reviews·Thomas BoehmMichael Schorpp

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