Linkage analysis of three candidate regions of chromosome 1 in nonsyndromic familial orofacial cleft

Annals of Human Genetics
Marcella MartinelliMauro Tognon

Abstract

Linkage analysis and mouse model knockout studies indicate that loci/genes mapping in different chromosome 1 regions are good candidates for nonsyndromic orofacial cleft (OFC) malformation. On this basis, three different regions of the chromosome 1 have been analysed, by linkage analysis, in 38 families with nonsyndromic OFC. Positive scores were obtained by pairwise analysis and a non-parametric linkage approach for the 1p36 region, with markers close to the MTHFR locus. Additional results allowed us to exclude the presence of an OFC susceptibility gene in the 1q21 and 1q32-42.3 regions.

Citations

Feb 12, 2000·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Francesco CarinciMauro Tognon
Nov 3, 2009·Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India·Jyotsna Murthy, Lvks Bhaskar
May 29, 2002·Clinical Genetics·J C Murray
Jun 25, 2003·Journal of Dental Research·Francesco CarinciS Volinia
Jan 10, 2009·Journal of Dental Research·L MengJ W Von den Hoff
Mar 7, 2003·The Journal of Craniofacial Surgery·Francesco CarinciMauro Tognon
Dec 18, 2007·L' Orthodontie française·William BaconFabienne Perrin-Schmitt
Nov 13, 2007·The Journal of Craniofacial Surgery·Rosario RulloFrancesco Carinci
Oct 23, 2003·European Journal of Human Genetics : EJHG·Joanna S ZeigerIain McIntosh
Jun 3, 2015·American Journal of Medical Genetics. Part a·Hanneke BasartRaoul C Hennekam

Related Concepts

Oxidoreductases Acting on CH-NH Group Donors
Chromosomes, Human, Pair 1
Cleft Lip
Cleft Palate, Isolated
Genetic Linkage Analysis
Genealogical Tree
Spearman Rank Correlation Coefficient
Tetranucleotide Repeats
Methylenetetrahydrofolate reductase (NADPH)

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