Linkage and association between inflammatory bowel disease and a locus on chromosome 12

American Journal of Human Genetics
Richard H DuerrC E Aston

Abstract

Genetic epidemiological studies have shown that genetic factors are important in the pathogenesis of the idiopathic inflammatory bowel diseases (IBD), Crohn disease (CD), and ulcerative colitis (UC). A genome screen in the United Kingdom found linkage of IBD to a 41-cM region of chromosome 12, surrounding D12S83. We aimed to replicate this linkage and to narrow the region of interest. Nonparametric linkage analyses at microsatellites surrounding D12S83 were performed in 122 North American Caucasian families containing 208 genotyped IBD-affected relative pairs. Transmission/disequilibrium tests (TDTs) were also performed. We confirmed that IBD is linked to chromosome 12 (peak GENEHUNTER-PLUS LOD* score 2.76 [P = .00016] between D12S1724 and D12S90). The evidence for linkage is contributed by both the group of CD-affected relative pairs (peak GENEHUNTER-PLUS LOD* score 1.79 [P = .0021] between D12S1724 and D12S90) and the group of UC-affected relative pairs (peak GENEHUNTER-PLUS LOD* score 1.82 [P = .0019] at D12S335). The TDT is positive at the D12S83 locus (global chi2 = 16.41, 6 df, P = .012). In conclusion, we have independently confirmed linkage of IBD to the chromosome 12 region that we investigated. A positive TDT at D12S8...Continue Reading

References

Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·A CollinsN E Morton
Nov 5, 1997·American Journal of Human Genetics·A Kong, N J Cox

❮ Previous
Next ❯

Citations

Feb 21, 2008·Inflammatory Bowel Diseases·David Underhill, Jonathan Braun
Jan 15, 1999·Pathology Oncology Research : POR·R Naidoo, R Chetty
Jul 6, 2005·Der Internist·J WedemeyerM J Bahr
Mar 7, 2001·European Journal of Pharmacology·A Császár, T Abel
Jun 14, 2003·Gastroenterology·Bjarni ThjodleifssonIngvar Bjarnason
Jul 5, 2003·The Journal of Surgical Research·Hideki MasudaTadatoshi Takayama
Feb 24, 2001·The Surgical Clinics of North America·J M Church
Jan 13, 2000·Current Opinion in Immunology·M F Moffatt, W O Cookson
Sep 1, 2000·European Journal of Internal Medicine·A PeraG Rocca
Jan 16, 1999·Current Opinion in Biotechnology·J Bell
Oct 3, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A GorisK Vandenbroeck
Oct 7, 2006·Current Opinion in Gastroenterology·S Schreiber, J Hampe
Oct 13, 2006·Current Opinion in Gastroenterology·S Schreiber, J Hampe
Oct 13, 2006·Current Opinion in Gastroenterology·Jean-Pierre Hugot, Judy H Cho
Feb 11, 2005·Current Opinion in Gastroenterology·T AhmadDerek Jewell
Oct 18, 2003·Journal of Clinical Gastroenterology·Richard H Duerr
Jun 1, 2000·Inflammatory Bowel Diseases·P C StokkersS J van Deventer
Apr 3, 2004·Inflammatory Bowel Diseases·M Michael BarmadaRichard H Duerr
Apr 16, 2002·Gut·D A Watts, J Satsangi
Aug 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·L DumoutierJ C Renauld
Dec 21, 2002·Immunological Reviews·William Cookson
May 21, 2005·Journal of Gastroenterology·Yoshitaka KinouchiTooru Shimosegawa
Feb 28, 2003·Expert Opinion on Investigational Drugs·Jeffrey A Tuvlin, Sunanda V Kane
Jun 9, 2016·Open Access Macedonian Journal of Medical Sciences·Miodraga Stefanovska PetkovskaVesna Velikj Stefanovska
Mar 15, 2002·Chest·William Osmond Charles Cookson
Oct 21, 2004·The Journal of Pathology·D W Owens, E B Lane
May 19, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Guo-Zhong TaoRichard H Duerr

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.