Linkage and association of schizophrenia with genetic variations in the locus of neuregulin 1 in Korean population

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Jong Won KimKyung Sue Hong

Abstract

Chromosome 8p21-12 has been reported to be a susceptibility locus for schizophrenia based on genome-wide linkage scans. After neuregulin 1 (NRG1) was identified as a positional candidate gene for schizophrenia in this locus, several independent association studies have reported controversial results. To determine whether genetic variations in this locus are associated with schizophrenia in the Korean population, we investigated multiplex families and unrelated patients using linkage and association analyses. Seven microsatellite markers in 8p21-12 were genotyped for 40 families with schizophrenia, and a non-parametric linkage analysis was applied. The association study was performed with 242 unrelated schizophrenia patients and the same number of normal controls for three single nucleotide polymorphisms (SNPs), two microsatellite markers and their haplotypes. A significant linkage signal was observed on D8S1769, which is located 352 kb upstream of the 5' end of the first exon of NRG1 for two ("narrow" and "narrow with auditory hallucination (AH)") of the three adopted phenotype classes. In the association study, the G allele of SNP8NRG241930 was significantly in excess in the subgroup of patients with AHs. We also found haploty...Continue Reading

References

Jun 19, 1995·American Journal of Medical Genetics·A E PulverH Chen
Sep 10, 1998·Nature Genetics·J L BlouinA E Pulver
Sep 16, 1999·American Journal of Human Genetics·L M BrzustowiczA S Bassett
May 17, 2000·American Journal of Medical Genetics·A G Cardno, I I Gottesman
Dec 13, 2002·American Journal of Human Genetics·Hreinn StefanssonDavid St Clair
Mar 22, 2003·Experimental Cell Research·Douglas L Falls
Jun 17, 2003·Molecular Psychiatry·N M WilliamsM J Owen
Jul 23, 2003·Molecular Psychiatry·J Z YangD Zhang
Dec 31, 2003·Molecular Psychiatry·N IwataN Ozaki
Mar 6, 2004·Annals of Medicine·Hreinn StefanssonKari Stefansson
May 5, 2004·Comprehensive Psychiatry·Eun-Jeong JooYong Sik Kim
May 27, 2004·Nature Neuroscience·Gabriel CorfasJoseph D Buxbaum

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Citations

Jul 4, 2009·European Archives of Psychiatry and Clinical Neuroscience·H Magnus HaraldssonHannes Petursson
Sep 21, 2007·Current Psychiatry Reports·Adriana FosterPeter Buckley
May 14, 2008·Current Psychiatry Reports·Jennifer Gladys Mulle
May 15, 2008·Nature Reviews. Neuroscience·Lin Mei, Wen-Cheng Xiong
Oct 12, 2010·Schizophrenia Research·Adel BarakatGeneviève Evin
May 4, 2010·Neuroscience Letters·Rosie M WalkerKathryn L Evans
Mar 7, 2009·Schizophrenia Research·H W WienerR C P Go
Jan 8, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Fernando S GoesUNKNOWN NIMH Genetics Initiative Bipolar Disorder Consortium
Nov 5, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Kyung Sue HongJong-Won Kim
Jan 15, 2011·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Sergi PapiolHannelore Ehrenreich
May 25, 2007·Neuron·Ran-Sook WooLin Mei
May 10, 2008·Biological Psychiatry·Lyudmila GeorgievaMichael C O'Donovan
Jun 11, 2016·Neuroscience and Biobehavioral Reviews·Md Shaki MostaidChad A Bousman
Jul 31, 2007·Human Mutation·Tine Venken, Jurgen Del-Favero
Apr 7, 2007·Psychiatric Genetics·Kyeong-Sook ChoiKyung Sue Hong
Oct 28, 2019·Frontiers in Psychology·Dan WangUNKNOWN GeseDNA Research Team
Oct 11, 2017·Frontiers in Molecular Neuroscience·Zhengrong ZhangRena Li

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