Linkage and association of the glutamate receptor 6 gene with autism

Molecular Psychiatry
S JamainParis Autism Research International Sibpair (PARIS) Study

Abstract

A genome scan was previously performed and pointed to chromosome 6q21 as a candidate region for autism. This region contains the glutamate receptor 6 (GluR6 or GRIK2) gene, a functional candidate for the syndrome. Glutamate is the principal excitatory neurotransmitter in the brain and is directly involved in cognitive functions such as memory and learning. We used two different approaches, the affected sib-pair (ASP) method and the transmission disequilibrium test (TDT), to investigate the linkage and association between GluR6 and autism. The ASP method, conducted with additional markers on the 51 original families and in eight new sibling pairs, showed a significant excess of allele sharing, generating an elevated multipoint maximum LOD score (ASPEX MLS = 3.28). TDT analysis, performed in the ASP families and in an independent data set of 107 parent-offspring trios, indicated a significant maternal transmission disequilibrium (TDTall P = 0.0004). Furthermore, TDT analysis (with only one affected proband per family) showed significant association between GluR6 and autism (TDT association P = 0.008). In contrast to maternal transmission, paternal transmission of GluR6 alleles was as expected in the absence of linkage, suggesting...Continue Reading

References

May 1, 1989·Journal of Child Psychology and Psychiatry, and Allied Disciplines·S SteffenburgM Bohman
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·A E WalterM Zuker
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J Egebjerg, S F Heinemann
Jan 1, 1995·Psychological Medicine·A BaileyM Rutter
Jan 1, 1994·Annual Review of Neuroscience·M Hollmann, S Heinemann
May 1, 1993·Acta Psychiatrica Scandinavica·L H RolfH Kehrer
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·A HerbP H Seeburg
Jan 22, 1996·Brain Research. Developmental Brain Research·J SchmittW Paschen
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·D C RubinszteinD Craufurd
Nov 5, 1997·American Journal of Human Genetics·A Kong, N J Cox
Feb 5, 1998·Annals of Neurology·I Rapin, R Katzman
Oct 29, 1998·Cellular and Molecular Life Sciences : CMLS·C M Niswender
Apr 2, 1999·Trends in Pharmacological Sciences·R ChittajalluJ M Henley
Apr 10, 1999·Human Molecular Genetics·A PhilippeL van Malldergerme
Jul 14, 1999·American Journal of Medical Genetics·M MartinezP V Gejman
Jul 17, 1999·Acta Psychiatrica Scandinavica·C Gillberg, L Wing
Jul 27, 1999·American Journal of Human Genetics·N RischR M Myers
Nov 24, 1999·Genomics·A Ashley-KochM A Pericak-Vance
Dec 3, 1999·American Journal of Medical Genetics·S BarrettS Slager
Mar 4, 2000·Human Molecular Genetics·R J GardnerD O Robinson
Mar 17, 2000·Brain Research. Brain Research Reviews·J H Meador-Woodruff, D J Healy
Apr 15, 2000·American Journal of Medical Genetics·J H Miles, R E Hillman
Jul 18, 2000·American Journal of Medical Genetics·C M WolpertM A Pericak-Vance
Nov 14, 2000·Trends in Neurosciences·Y Ben-Ari, R Cossart
Feb 15, 2001·Trends in Genetics : TIG·R A Reenan

❮ Previous
Next ❯

Citations

Oct 4, 2006·Psychopharmacology·Craig A EricksonChristopher J McDougle
Sep 19, 2012·European Archives of Psychiatry and Clinical Neuroscience·Gagan JoshiAtilla Gönenç
Jul 19, 2006·Cell and Tissue Research·Paulo Pinheiro, Christophe Mulle
Sep 5, 2009·Cellular and Molecular Neurobiology·Janaki VallipuramDorota A Crawford
May 9, 2012·Journal of Computational Neuroscience·Reyhaneh BakhtiariHossein Esteky
Mar 30, 2004·Brain Research. Molecular Brain Research·C M Martin-RuizE K Perry
Nov 26, 2002·Trends in Genetics : TIG·Eunju SeongMargit Burmeister
Jan 29, 2003·Current Opinion in Pharmacology·Michael SpeddingLaszlo Harsing
Dec 25, 2013·Journal of the International Neuropsychological Society : JINS·Yukari TakaraeJohn A Sweeney
Jan 6, 2011·European Journal of Human Genetics : EJHG·Andrew McQuillinHugh Gurling
May 6, 2010·European Journal of Human Genetics : EJHG·Richard HoltUNKNOWN EU Autism MOLGEN Consortium
Apr 2, 2003·Nature Genetics·Stéphane JamainUNKNOWN Paris Autism Research International Sibpair Study
Apr 17, 2008·Nature Reviews. Genetics·Brett S Abrahams, Daniel H Geschwind
Jan 17, 2008·Médecine sciences : M/S·Christelle M DurandThomas Bourgeron
Feb 18, 2006·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Helen E Penn
Aug 10, 2011·Journal of Child and Adolescent Psychopharmacology·Logan K WinkChristopher J McDougle
Dec 25, 2002·Journal of the American Academy of Child and Adolescent Psychiatry·Jeremy Veenstra-VanderweelePaul J Lombroso
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·T Bourgeron
Sep 12, 2008·Biological Reviews of the Cambridge Philosophical Society·Bernard Crespi
Oct 16, 2004·Annual Review of Genomics and Human Genetics·Jeremy Veenstra-VanderweeleEdwin H Cook
Dec 15, 2006·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Nathalie Strutz-SeebohmGuiscard Seebohm
Jun 26, 2010·Annals of General Psychiatry·Michiko NakazatoJanet Treasure
Aug 2, 2012·Genome Biology·Jamee M Berg, Daniel H Geschwind
Aug 10, 2013·Disease Models & Mechanisms·Kara G Pratt, Arseny S Khakhalin
Nov 22, 2011·PLoS Genetics·Santhosh GirirajanEvan E Eichler
Nov 20, 2002·Pharmacogenomics·Alan R SandersPablo V Gejman
Apr 9, 2005·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Susan L Santangelo, Katherine Tsatsanis
Aug 5, 2005·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Diane Hu-LinceDietrich A Stephan
Nov 30, 2011·Epigenomics·Kristin D Kernohan, Nathalie G Bérubé
Aug 9, 2013·International Journal of Environmental Research and Public Health·Ilona QuaakMargot Van de Bor
Feb 13, 2014·Translational Psychiatry·D A RossignolR E Frye
Feb 5, 2014·Journal of Neural Transmission·Andreas G ChiocchettiChristine M Freitag

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Related Papers

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Mei ShuangDai Zhang
Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Nathalie Strutz-SeebohmGuiscard Seebohm
© 2022 Meta ULC. All rights reserved