Linkage between the mechanisms of thrombocytopenia and thrombopoiesis.

Blood
Koji Eto, Shinji Kunishima

Abstract

Thrombocytopenia is defined as a status in which platelet numbers are reduced. Imbalance between the homeostatic regulation of platelet generation and destruction is 1 potential cause of thrombocytopenia. In adults, platelet generation is a 2-stage process entailing the differentiation of hematopoietic stem cells into mature megakaryocytes (MKs; known as megakaryopoiesis) and release of platelets from MKs (known as thrombopoiesis or platelet biogenesis). Until recently, information about the genetic defects responsible for congenital thrombocytopenia was only available for a few forms of the disease. However, investigations over the past 15 years have identified mutations in genes encoding >20 different proteins that are responsible for these disorders, which has advanced our understanding of megakaryopoiesis and thrombopoiesis. The underlying pathogenic mechanisms can be categorized as (1) defects in MK lineage commitment and differentiation, (2) defects in MK maturation, and (3) defect in platelet release. Using these developmental stage categories, we here update recently described mechanisms underlying megakaryopoiesis and thrombopoiesis and discuss the association between platelet generation systems and thrombocytopenia.

References

Sep 2, 1994·Science·A L GurneyM W Moore
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·K IharaT Hara
Mar 21, 2000·Biochimica Et Biophysica Acta·J R Sellers
Jan 21, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Shinji KunishimaHidehiko Saito
Nov 5, 2003·Thrombosis and Haemostasis·Remi FavierElisabeth M Cramer
Dec 12, 2003·Development·Anne M Boulet, Mario R Capecchi
Jul 3, 2004·The Journal of Clinical Investigation·Hana RaslovaRémi Favier
Sep 1, 2004·The Journal of Experimental Medicine·Wei Tong, Harvey F Lodish
Sep 16, 2005·Human Molecular Genetics·Alessandro PecciMauro Torti
Dec 3, 2005·The Journal of Clinical Investigation·Sunita R PatelJoseph E Italiano
Jan 5, 2007·Annual Review of Immunology·Ana Cumano, Isabelle Godin
Jan 25, 2007·Blood·Yunhua ChangNajet Debili
Feb 10, 2007·Blood·David J Kuter
Jul 12, 2008·European Journal of Haematology·Shinji KunishimaHidehiko Saito
Dec 2, 2008·Cell Stem Cell·Ann C ZoveinM Luisa Iruela-Arispe
Dec 11, 2008·Journal of Thrombosis and Haemostasis : JTH·A BalduiniC L Balduini
Mar 10, 2009·Orphanet Journal of Rare Diseases·Teresa MattinaPaul Grossfeld
Jul 3, 2009·Thrombosis and Haemostasis·Alessandro PecciAlessandra Balduini
Jan 21, 2010·Blood·Hansjörg SchwertzAndrew S Weyrich
Apr 28, 2010·The Journal of Experimental Medicine·Yohei MoritaHiromitsu Nakauchi

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Citations

Apr 29, 2016·Journal of Thrombosis and Haemostasis : JTH·K KitamuraS Kunishima
Apr 26, 2017·British Journal of Haematology·Yuri UchiyamaNaomichi Matsumoto
Jul 21, 2020·PLoS Neglected Tropical Diseases·João Conrado Khouri Dos-SantosFabio Trindade Maranhão Costa
Jul 29, 2017·Scientific Reports·Lee ButcherJorge D Erusalimsky
Apr 20, 2019·Blood·Naoshi Sugimoto, Koji Eto
Nov 1, 2020·Cytokine·Arkajyoti MukherjeeArup Sarkar
Aug 15, 2019·Oncology Reviews·Ali Amin AsnafiNajmaldin Saki
Nov 24, 2020·Platelets·Jaturawat PawinwongchaiPonlapat Rojnuckarin
Jun 19, 2021·Signal Transduction and Targeted Therapy·Hong-Yan ZhaoXiao-Jun Huang
Jun 1, 2021·Pigment Cell & Melanoma Research·Zilin ZhongJianjun Chen
Sep 7, 2021·Frontiers in Cell and Developmental Biology·Hong LiJianming Wu

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