Linkage disequilibrium between the pseudoautosomal PEPB-1 locus and the sex-determining region of chinook salmon

Heredity
A R MarshallF W Allendorf

Abstract

Allele frequency differences between sexes and an excess of heterozygotes in males had suggested that the PEPB-1 locus is sex-linked in chinook salmon (Oncorhynchus tshawytscha). We here estimate less than 1% recombination between PEPB-1 and a growth hormone pseudogene known to be in the sex-determining region (SEX) in 374 progeny from eight experimental matings. We present modified maximum likelihood methods for estimating haplotype frequencies from population samples at a sex-linked locus in which functional alleles occur on both the X and Y chromosomes (pseudoautosomal loci). We find nearly complete linkage disequilibrium between PEPB-1 and SEX in 20 population samples from the Puget Sound region of Washington and southern British Columbia. However, allele frequencies at PEPB-1 were similar in males and females in 35 population samples from the coast of Washington and the Columbia River basin. Pseudoautosomal regions have been described in a broad taxonomic array of vertebrates and invertebrates, and they are likely candidate regions to find genes associated with differences in life history, morphology, or behavior between males and females.

References

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Citations

Nov 6, 2009·Heredity·M H Li, J Merilä
Jun 3, 2005·Heredity·D CharlesworthG Marais
Jul 28, 2009·Annual Review of Genomics and Human Genetics·Melissa A Wilson, Kateryna D Makova
Nov 9, 2006·Evolution; International Journal of Organic Evolution·Ivan Scotti, Lynda F Delph
Nov 27, 2014·The Journal of Heredity·Robin S Waples
Mar 30, 2017·Frontiers in Genetics·Maryn O CarlsonChristine D Smart
Dec 10, 2020·Evolutionary Applications·Garrett J McKinneyLisa W Seeb

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