Linkage disequilibrium on the bovine X chromosome: characterization and use in quantitative trait locus mapping.

Genetics
Cynthia SandorMichel Georges

Abstract

We herein demonstrate that in the Holstein-Friesian dairy cattle population, microsatellites are as polymorphic on the X chromosome as on the autosomes but that the level of linkage disequilibrium between these markers is higher on the X chromosome than on the autosomes. The latter observation is not compatible with the small male-to-female ratio that prevails in this population and results in a higher gonosomal than autosomal effective population size. It suggests that the X chromosome undergoes distinct selective or mutational forces. We describe and characterize a novel Markovian approach to exploit this linkage disequilibrium to compute the probability that two chromosomes are identical-by-descent conditional on flanking marker data. We use the ensuing probabilities in a restricted maximum-likelihood approach to search for quantitative trait loci (QTL) affecting 48 traits of importance to the dairy industry and provide evidence for the presence of QTL affecting 5 of these traits on the bovine X chromosome.

References

Jul 10, 1998·Mammalian Genome : Official Journal of the International Mammalian Genome Society·W CoppietersM Georges
Feb 15, 2000·Genome Research·F FarnirM Georges
Mar 10, 2001·Nature·R SachidanandamUNKNOWN International SNP Map Working Group
Apr 6, 2001·Genetics·T H MeuwissenM E Goddard
Jun 26, 2001·Animal Genetics·T S SonstegardC C Yeh
Dec 18, 2001·Genetics, Selection, Evolution : GSE·T H Meuwissen, M E Goddard
Dec 24, 2003·The Journal of Heredity·S HiendlederG Erhardt
Jan 7, 2004·Nature Reviews. Genetics·Stephen F Schaffner
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Bernard GrisartMichel Georges
Oct 7, 2004·Genome Research·Naoya IharaYoshikazu Sugimoto
Oct 29, 2005·Nature·UNKNOWN International HapMap Consortium

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Citations

Jun 3, 2010·Genetics Research·Daniel GianolaSaber Qanbari
Nov 6, 2009·Heredity·M H Li, J Merilä
May 5, 2007·Annual Review of Genomics and Human Genetics·Michel Georges
Jul 9, 2010·BMC Genomics·Jarmila BohmanovaFlavio S Schenkel
Jul 26, 2014·Annual Review of Cell and Developmental Biology·Jeffrey J Schoenebeck, Elaine A Ostrander
Apr 17, 2009·Molecular Ecology·Jenny HagenbladHans Ellegren
Jul 18, 2016·Journal of Dairy Science·Xiaowei MaoDirk-Jan De Koning
Apr 19, 2008·Journal of Dairy Science·M SargolzaeiL R Schaeffer
Dec 26, 2008·Journal of Dairy Science·P M VanRadenF S Schenkel
May 18, 2016·Genetics·Dirk-Jan de Koning
Aug 22, 2007·Journal of Animal Science·E M SellnerJ F Taylor
Aug 21, 2020·Genetics, Selection, Evolution : GSE·Tom Druet, Andres Legarra

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