PMID: 8469933Apr 1, 1993Paper

Linkage disequilibrium within the HLA complex does not extend into HLA-DP

Scandinavian Journal of Immunology
J M Baisch, J D Capra

Abstract

It is well known that certain alleles from different loci within the Human Leucocyte Antigen (HLA) complex are in linkage disequilibrium. This linkage phenomenon is relatively well characterized for haplotypes that include specific class I and class II alleles such as HLA-B8 and HLA-DR3. However, the HLA-DP genes are located at the centromeric end of the HLA complex and are less well characterized with regard to linkage disequilibrium. The availability of a large population of healthy subjects and sequence-specific oligonucleotide (SSO) typing enabled us to assess the degree of linkage between HLA-DPB1 and HLA-DQB1 genes. Using the polymerase chain reaction and a series of oligonucleotide probes which define seven DQ beta alleles and twenty DP beta alleles, we studied 180 unrelated, normal Caucasian individuals and found only weak or negative associations between HLA-DPB1 and HLA-DQB1. These data demonstrate that the association between HLA-DQ and DP is weak and also imply that DP extended haplotypes related to particular diseases may not reflect normal associations. Implications of these results might impact on the concept of linkage disequilibrium in general as well as the evolution of the HLA complex. In addition, extensions...Continue Reading

References

Jun 28, 1990·The New England Journal of Medicine·J M BaischJ D Capra
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Citations

Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·H K MachullaJ Langner
Jul 8, 1999·Tissue Antigens·F Migot-NabiasA J Georges
Aug 10, 2000·Scandinavian Journal of Immunology·H K MacHullaJ Langner
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D G Jackson, J D Capra
Jan 15, 2010·Tissue Antigens·E V A BillenE M van den Berg-Loonen
Aug 24, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·V StephanK A Deichmann
Feb 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J G MellaB A Volk

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