Linkage Map of Lissotriton Newts Provides Insight into the Genetic Basis of Reproductive Isolation

G3 : Genes - Genomes - Genetics
Marta NiedzickaWieslaw Babik

Abstract

Linkage maps are widely used to investigate structure, function, and evolution of genomes. In speciation research, maps facilitate the study of the genetic architecture of reproductive isolation by allowing identification of genomic regions underlying reduced fitness of hybrids. Here we present a linkage map for European newts of the Lissotriton vulgaris species complex, constructed using two families of F2 L. montandoni × L. vulgaris hybrids. The map consists of 1146 protein-coding genes on 12 linkage groups, equal to the haploid chromosome number, with a total length of 1484 cM (1.29 cM per marker). It is notably shorter than two other maps available for salamanders, but the differences in map length are consistent with cytogenetic estimates of the number of chiasmata per chromosomal arm. Thus, large salamander genomes do not necessarily translate into long linkage maps, as previously suggested. Consequently, salamanders are an excellent model to study evolutionary consequences of recombination rate variation in taxa with large genomes and a similar number of chromosomes. A complex pattern of transmission ratio distortion (TRD) was detected: TRD occurred mostly in one family, in one breeding season, and was clustered in two g...Continue Reading

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Citations

Aug 17, 2018·Proceedings. Biological Sciences·Anna FijarczykWiesław Babik
Oct 2, 2019·Molecular Ecology·Katarzyna DudekWiesław Babik
Sep 25, 2019·Molecular Ecology·Piotr ZielińskiWiesław Babik

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Methods Mentioned

BETA
genotyping

Software Mentioned

MapChart
GenomeAnalysisTK UnifiedGenotyper
MergeMap
RECORD
Bowtie2
R
onemap
R EMT
Genepop
GATK

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