Linkage mapping of the angiotensin AT2 receptor gene (Agtr2) to the mouse X chromosome

Genomics
L HeinG S Barsh

Abstract

Angiotensin II is a potent regulator of cardiovascular homeostasis and binds to two different G-protein-coupled receptors. While the type 1 receptor (AT1) mediates the cardiovascular actions of angiotensin II, the function of the recently cloned type 2 receptor (AT2) remains unknown. We have cloned the mouse AT2 receptor gene (Agtr2) and determined its map position by linkage analysis using an interspecific backcross (C57BL/6J x Mus spretus).Agtr2 is located on the proximal mouse X chromosome between DXMit85 and DXMit49, in a region of conserved synteny with a part of the human X chromosome implicated in inherited forms of premature ovarian failure. The mapping of Agtr2 may expand a region of conserved synteny with human Xq26 that includes Hprt.

Citations

Dec 1, 1996·Mammalian Genome : Official Journal of the International Mammalian Genome Society·L B RoweE H Birkenmeier
Mar 7, 2000·Journal of Hypertension·T Unger
Jun 1, 2001·Regulatory Peptides·M Stoll, T Unger

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