Linkage of aerobic glycolysis to sodium-potassium transport in rat skeletal muscle. Implications for increased muscle lactate production in sepsis

The Journal of Clinical Investigation
J H JamesJ E Fischer

Abstract

Although a linkage between aerobic glycolysis and sodium-potassium transport has been demonstrated in diaphragm, vascular smooth muscle, and other cells, it is not known whether this linkage occurs in skeletal muscle generally. Metabolism of intact hind-leg muscles from young rats was studied in vitro under aerobic incubation conditions. When sodium influx into rat extensor digitorum longus (EDL) and soleus muscles was facilitated by the sodium ionophore monensin, muscle weight gain and production of lactate and alanine were markedly stimulated in a dose-dependent manner. Although lactate production rose in both muscles, it was more pronounced in EDL than in soleus. Monensin-induced lactate production was inhibited by ouabain or by incubation in sodium-free medium. Preincubation in potassium-free medium followed by potassium re-addition also stimulated ouabain-inhibitable lactate release. Replacement of glucose in the incubation medium with pyruvate abolished monensin-induced lactate production but exacerbated monensin-induced weight gain. Muscles from septic or endotoxin-treated rats exhibited an increased rate of lactate production in vitro that was partially inhibited by ouabain. Increases muscle lactate production in sepsis...Continue Reading

References

Jan 1, 1992·Critical Care Medicine·B A Mizock, J L Falk
Aug 1, 1992·Acta Physiologica Scandinavica·M E Everts, T Clausen
Mar 13, 1992·Science·B L KaganB J Wisnieski
Mar 18, 1992·JAMA : the Journal of the American Medical Association·R S Hotchkiss, I E Karl
Feb 17, 1992·Biochimica Et Biophysica Acta·A Hoya, R A Venosa
Nov 1, 1991·Metabolism: Clinical and Experimental·U AngeråsJ E Fischer
Jun 1, 1990·Journal of Pediatric Surgery·R J Hannon, V E Boston
Sep 23, 1986·European Journal of Pharmacology·R H KennedyR Kafiluddi
Jan 1, 1989·The Journal of Surgical Research·S ShionoG T Shires
Jan 1, 1989·Life Sciences·J M Fagan, M E Tischler
Oct 1, 1986·The Journal of Experimental Medicine·K J TraceyG T Shires
Nov 21, 1985·Biochimica Et Biophysica Acta·I BihlerP Charles
Sep 1, 1980·The Journal of Trauma·K Y LiawJ M Kinney
Aug 1, 1980·The Journal of Surgical Research·K A WichtermanI H Chaudry
Jul 1, 1995·The Journal of Surgical Research·Y MizobataD O Jacobs
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·L Pellerin, P J Magistretti
Jun 1, 1993·The Journal of Surgical Research·J H JamesJ E Fischer

❮ Previous
Next ❯

Citations

Jul 6, 2001·Muscle & Nerve·S DiMauro, C Lamperti
Jun 26, 2003·Journal of Biomedical Science·Chien-Cheng HsiehYing-Tung Lau
Sep 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·W A ChutkowC F Burant
May 7, 2002·Critical Care Medicine·Weiyang WangDanny O Jacobs
Dec 15, 2005·Critical Care Medicine·Richard J LevyClifford S Deutschman
Sep 22, 2007·Critical Care Medicine·Luc Tappy, René Chioléro
Jul 1, 2006·Current Opinion in Critical Care·Bruno Levy
Jun 24, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Qun Gao, Michael S Wolin
Sep 18, 2012·Critical Care : the Official Journal of the Critical Care Forum·Sébastien Gibot
Nov 10, 2005·Critical Care : the Official Journal of the Critical Care Forum·Kyle J Gunnerson
Mar 5, 2004·The Tohoku Journal of Experimental Medicine·Ken OkamotoChikanori Terai
Jan 12, 2010·Molecular Medicine·Miguel López-Lázaro
Mar 31, 2001·Intensive Care Medicine·J Bakker
Jul 14, 2014·The Veterinary Clinics of North America. Equine Practice·Brett Tennent-Brown
Nov 15, 2013·BioMed Research International·José GorrasiStephan M Jakob
Oct 29, 2015·British Journal of Anaesthesia·P Marik, R Bellomo
Aug 26, 1998·The Journal of Physiology·K E ConleyS A Jubrias
May 8, 2004·The Journal of Physiology·L B Gladden
Apr 17, 2004·The Journal of Investigative Dermatology·Noriaki NakagawaHideyo Uchiwa
Dec 12, 2012·Trends in Neurosciences·Andrew Lutas, Gary Yellen
May 31, 2011·The Surgical Clinics of North America·Josef E Fischer
Sep 2, 2010·Experimental and Molecular Pathology·Leonardo M R Ferreira
Oct 31, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C CaldeiraE A Burdmann
Apr 12, 2008·The Veterinary Clinics of North America. Small Animal Practice·Helio Autran de MoraisStephen P DiBartola
Mar 18, 2008·British Journal of Pharmacology·D TricaricoD C Camerino
Oct 20, 2001·Disease-a-month : DM·P E Marik, J Varon
Aug 2, 2007·Expert Opinion on Therapeutic Targets·Miguel López-Lázaro
Jul 27, 2001·The Journal of Surgical Research·F D McCarterJ E Fischer
May 17, 2008·Biochimica Et Biophysica Acta·Jane E Carré, Mervyn Singer
Jul 31, 2012·Biochimica Et Biophysica Acta·Philippe Icard, Hubert Lincet
May 4, 2000·The Journal of Surgical Research·K OkamotoD O Jacobs
May 25, 1999·JPEN. Journal of Parenteral and Enteral Nutrition·Y M YuV R Young
Jul 27, 1999·JPEN. Journal of Parenteral and Enteral Nutrition·V R Young, A M Ajami
Mar 14, 2018·Journal of Veterinary Emergency and Critical Care·Patricia G RosensteinDez Hughes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.