Linkage of schizophrenia with TPH2 and 5-HTR2A gene polymorphisms in the Malay population

Genetics and Molecular Research : GMR
S F TeeH C Loh

Abstract

The serotoninergic system has been implicated in the etiology of schizophrenia and other behavioral disorders. Association studies have focused on the tryptophan hydroxylase 2 gene (TPH2) and the 5-hydroxytryptamine receptor 2A gene (5-HTR2A). We genotyped two single-nucleotide polymorphisms, A1438G of 5-HTR2A and intronic rs1386494 of TPH2 in the Malay population, using a sample size of 289 schizophrenic patients and 130 healthy controls. We found a significant association of A1438G of 5-HTR2A with schizophrenia in Malays. On the other hand, TPH2 polymorphism was not associated with schizophrenia. This is the first genetic association study concerning schizophrenia in the Malay population.

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Citations

Mar 7, 2012·Journal of Molecular Neuroscience : MN·Zhenghui YiYiru Fang
Oct 16, 2012·Psychiatry Research·Hui-Chun TsuangHsien-Yuan Lane
Oct 8, 2014·Acta Neuropsychiatrica·Saliha Handan YildizEvrim Suna Arikan Terzi
May 12, 2012·Genetics and Molecular Research : GMR·H C LohS S J Singh
Apr 15, 2011·Genetics and Molecular Research : GMR·K C AngB M Md-Zain
Jun 5, 2012·Journal of Psychiatric Research·Anna SchuhmacherRainald Mössner
Aug 26, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shiqing ChenGuang He
Sep 7, 2016·Nordic Journal of Psychiatry·Li SunYi-Ping Liu

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