Linkage screen for BMD phenotypes in male and female COP and DA rat strains.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Daniel L KollerCharles H Turner

Abstract

Because particular inbred strains of experimental animals are informative for only a subset of the genes underlying variability in BMD, we undertook a genome screen to identify quantitative trait loci (QTLs) in 828 F(2) progeny (405 males and 423 females) derived from the Copenhagen 2331 (COP) and dark agouti (DA) strains of rats. This screen was performed to complement our study in female Fischer 344 (F344) and Lewis (LEW) rats and to further delineate the factors underlying the complex genetic architecture of BMD in the rat model. Microsatellite genotyping was performed using markers at an average density of 20 cM. BMD was measured by pQCT and DXA. These data were analyzed in the R/qtl software to detect QTLs acting in both sexes as well as those having sex-specific effects. A QTL was detected in both sexes on chromosome 18 for midfemur volumetric BMD (vBMD; genome-wide, p < 0.01). On distal chromosome 1, a QTL was found for femur and vertebral aBMD as well as distal femur vBMD, and this QTL appears distinct from the proximal chromosome 1 QTL impacting BMD in our F344/LEW cross. Additional aBMD and vBMD QTLs and several sex-specific QTLs were also detected. These included a male-specific QTL (p < 0.01) on chromosome 8 and a f...Continue Reading

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Oct 3, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Daniel L KollerCharles H Turner

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Citations

Oct 21, 2009·Functional & Integrative Genomics·Imranul AlamCharles H Turner
Jan 21, 2009·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Daniel L KollerCharles H Turner
Jul 13, 2016·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Kylie K HarrallLaura M Saba
Feb 2, 2016·PLoS Genetics·Anna L TylerGregory W Carter

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