PMID: 8593945Mar 1, 1996Paper

Linkage studies of NIDDM with 23 chromosome 11 markers in a sample of whites of northern European descent

Diabetes
S C ElbeinM F Leppert

Abstract

Considerable data support a genetic basis to susceptibility for NIDDM, but previous analysis of candidate genes has failed to identify a major susceptibility locus. Among regions with multiple potential candidates is chromosome 11, which includes the apolipoprotein C3 cluster, muscle glycogen phosphorylase, two insulin-dependent diabetes loci, the sulfonylurea receptor, and ataxia telangiectasia. To test linkage, we initially typed 19 markers at 10- to 15-cM intervals along chromosome 11. Analyses carried out under parametric models in members of 16-19 families of northern European ancestry detected possible linkage of NIDDM to D11S916. Nonparametric methods detected possible linkage to NIDDM at D11S901, which was 5- 10 cM distant, and at D11S935, which was approximately 30 cM distant. Both D11S916 and D11S901 were near the IDDM4 locus. To further test linkage, we typed five additional markers within 5 cM of D11S916 in the initial 19 families. We also tested markers from the linked region in a second set of recently sampled additional families. Two additional markers (D11S527 and D11S534) showed possible linkage in the initial 19 families, but none of the markers were linked to NIDDM in a separate set of families from the same ...Continue Reading

Citations

May 14, 1999·Trends in Endocrinology and Metabolism : TEM·M J DunneC Ämmälä
Apr 4, 2000·Diabetic Medicine : a Journal of the British Diabetic Association·M J Dunne
Jan 2, 2001·Endocrine Reviews·S MatthaeiH U Häring
Dec 31, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·T RanheimA D Attie

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