PMID: 9184317May 31, 1997Paper

Linkage study of chromosome 6p in sib-pairs with schizophrenia

American Journal of Medical Genetics
J K DanielsM J Owen

Abstract

Following reports of linkage between schizophrenia and markers in the chromosomal region 6p24-22 we have studied nine microsatellite markers spanning 40 cM of this region in our sample of 102 affected sibling pairs from 86 families. Allele sharing identity by descent was examined using likelihood based sib-pair analysis as implemented by the program SPLINK. No evidence for linkage was obtained and the highest lod score was only 0.192 for D6S309. We conclude that if there is a susceptibility locus for schizophrenia in this region then its effect size is so small as to render our study insufficiently powerful to detect it.

References

Jun 1, 1990·Archives of General Psychiatry·J K WingN Sartorius
May 1, 1974·The British Journal of Psychiatry : the Journal of Mental Science·L N Robins
Nov 1, 1995·Nature Genetics·B J MowryL Sharpe
Nov 1, 1995·Nature Genetics·H GurlingJ Brynjolfsson
Nov 1, 1995·Nature Genetics·S E AntonarakisB Dombroski
Sep 9, 1995·Lancet·P McGuffinA E Farmer

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Citations

Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·H D ShinM W Smith
Jun 22, 1999·American Journal of Medical Genetics·J I Nurnberger, T Foroud
Mar 11, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·A D SkolM T Tsuang

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