Linkage to nodal osteoarthritis: quantitative and qualitative analyses of data from a whole-genome screen identify trait-dependent susceptibility loci

Annals of the Rheumatic Diseases
C GreigGillian A Wallis

Abstract

To identify susceptibility loci for nodal osteoarthritis. A genome screen at an average marker spacing of 9.29 cM was carried out on 558 people from 202 families, of whom 491 had nodal osteoarthritis. All genotyped people were graded for the incidence and severity of distal interphalangeal (DIP) nodes, and radiographs from 354 people were graded for joint-space narrowing (JSN) and osteophytes (OSTs). Age-regressed indices for DIP nodes, JSN and OSTs were calculated using these phenotypic data. Affected sibling pair (ASP) and quantitative trait analyses were carried out using MERLIN. The data analysis identified suggestive linkage to loci on chromosomes 3 (for JSN and OST), 4 (for JSN), 8 (for DIP), 11 (for radiographic osteoarthritis) and 16 (for JSN). Both the ASP and quantitative analyses identified the loci on chromosomes 4 and 11. The loci on chromosomes 3 and 16 overlap with those previously identified for large-joint osteoarthritis. Of the loci identified by the quantitative analyses with the logarithm of the odds of linkage >1.5, two were linked to more than one trait, whereas nine were linked to single traits: one for DIP, six for JSN and two for OST. The ASP and quantitative analyses of the cohort with nodal osteoarthr...Continue Reading

References

Apr 13, 1996·BMJ : British Medical Journal·T D SpectorD Hart
Aug 16, 1997·Lancet·P Creamer, M C Hochberg
May 23, 1998·American Journal of Human Genetics·L Almasy, J Blangero
Jun 23, 1998·American Journal of Human Genetics·J R O'Connell, D E Weeks
Jun 12, 1999·American Journal of Human Genetics·K ChapmanJ Loughlin
Mar 11, 2000·American Journal of Human Genetics·M S McPeek, L Sun
Feb 27, 2001·Current Opinion in Rheumatology·J Loughlin
Dec 4, 2001·Nature Genetics·Gonçalo R AbecasisLon R Cardon
Apr 16, 2002·Arthritis and Rheumatism·S DemissieD T Felson
Jul 13, 2002·Arthritis and Rheumatism·John LoughlinKay Chapman
Dec 17, 2002·Arthritis and Rheumatism·Emma GillaspyTim D Spector
Feb 7, 2003·Arthritis and Rheumatism·Helgi JonssonKari Stefansson
Jan 20, 2004·Arthritis and Rheumatism·Lara KevorkianIan M Clark
Jan 26, 1952·British Medical Journal·J H KELLGREN, R MOORE
Apr 20, 2004·Osteoarthritis and Cartilage·A G SternH R Schumacher
Aug 31, 2004·Arthritis and Rheumatism·D J HunterD T Felson
Mar 5, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hui ShenHong-Wen Deng

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Citations

Nov 13, 2007·Zeitschrift für Rheumatologie·B Müller-Hilke
Sep 16, 2006·Annals of the Rheumatic Diseases·J Loughlin
Oct 26, 2010·Joint, Bone, Spine : Revue Du Rhumatisme·Laëtitia Michou
Apr 1, 2009·Arthritis and Rheumatism·Nigel K ArdenMichael Nevitt
Jul 1, 2007·Expert Review of Clinical Immunology·Charlene J Williams

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