journal cover

Linked read sequencing resolves complex genomic rearrangements in gastric cancer metastases

Genome Medicine

Jun 21, 2017

Stephanie GreerHanlee P Ji

Abstract

Genome rearrangements are critical oncogenic driver events in many malignancies. However, the identification and resolution of the structure of cancer genomic rearrangements remain challenging even with whole genome sequencing. To identify oncogenic genomic rearrangements and resolve th...read more

Mentioned in this Paper

Study
Size
Dermatofibrosarcoma Protuberans
FGFR2
Genome
Malignant Neoplasm of Stomach
Stomach Carcinoma
Three-dimensional
Inversion Mutation Abnormality
FGFR2 gene
62
2
1
93
Paper Details
References
  • References41
  • Citations12
12345
  • References41
  • Citations12
12

Feeds With Similar Papers

Cancer Genomics

Cancer genomics employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research here.

Chromosomal Deletion

Chromosomal deletion includes the loss of a gene sequence of DNA. The location and the genes deleted determines the significance of this abnormality. There are many identified genetic disorders that are a result from chromosomal deletion including cri du chat and Prader-Willi syndrome. Discover the latest research on chromosomal deletions here.

Comparative Sequencing

Inter/Intra-Species: Comparative Sequencing describes the sequencing techniques that compare between and within species genomes. Discover the latest research on comparative sequencing of inter/intra-species here.

Chromosomal Duplication

Chromosomal duplication is a result of extra genetic material within the area of the chromosome. The duplication may have no effect or may be expressed in the phenotype of that individual. Some duplications are thought to be of evolutionary selection. Discover the latest research on chromosomal duplication here.

Stanford Department of Genetics

Find the latest research from the Stanford Medicine Department of Genetics here.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Human Tumor Atlas Network (HTAN)

The Human Tumor Atlas Network is a collaborative network that aims to construct 3D atlases of the cellular, morphological, and molecular features of human cancers over time. Here is the latest research from researchers in the Human Tumor Atlas Network.

Open Access Genomics Journals

Discover the latest genomics research in this collection of the top open access genomics journals.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Organoids

Organoids are three-dimensional structures derived from adult or embryonic stem cells, tissues, or tumors, that enable the mimicry of in vivo architecture in tissue culture. Here is the latest research on organoids.

Related Papers

Advances in Modern Oncology Research

Multi-omics approach to infer cancer therapeutic targets on chromosome 20q across tumor types

Advances in Modern Oncology ResearchSeptember 20, 2016
Antoine M Snijders, Jian-Hua Mao
© 2020 Meta ULC. All rights reserved

Linked read sequencing resolves complex genomic rearrangements in gastric cancer metastases

Genome Medicine

Jun 21, 2017

Stephanie GreerHanlee P Ji

PMID: 28629429

DOI: 10.1186/s13073-017-0447-8

Abstract

Genome rearrangements are critical oncogenic driver events in many malignancies. However, the identification and resolution of the structure of cancer genomic rearrangements remain challenging even with whole genome sequencing. To identify oncogenic genomic rearrangements and resolve th...read more

Mentioned in this Paper

Study
Size
Dermatofibrosarcoma Protuberans
FGFR2
Genome
Malignant Neoplasm of Stomach
Stomach Carcinoma
Three-dimensional
Inversion Mutation Abnormality
FGFR2 gene
62
2
1
93

Feeds With Similar Papers

Cancer Genomics

Cancer genomics employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research here.

Chromosomal Deletion

Chromosomal deletion includes the loss of a gene sequence of DNA. The location and the genes deleted determines the significance of this abnormality. There are many identified genetic disorders that are a result from chromosomal deletion including cri du chat and Prader-Willi syndrome. Discover the latest research on chromosomal deletions here.

Related Papers

Advances in Modern Oncology Research

Multi-omics approach to infer cancer therapeutic targets on chromosome 20q across tumor types

Advances in Modern Oncology ResearchSeptember 20, 2016
Antoine M Snijders, Jian-Hua Mao
Paper Details
References
  • References41
  • Citations12
12345
  • References41
  • Citations12
12

Download from

Publisher
PubMed
/papers/linked-read-sequencing-resolves-complex-genomic/28629429