Linked selection, demography and the evolution of correlated genomic landscapes in birds and beyond

Molecular Ecology
Reto Burri


Selection has a deep impact on the distribution of genetic diversity and population differentiation along the genome (the genomic landscapes of diversity and differentiation), reducing diversity and elevating differentiation not only at the sites it targets, but also at linked neutral sites. Fuelled by the high-throughput sequencing revolution, these genomic footprints of selection have been extensively exploited over the past decade with the aim to identify genomic regions involved in adaptation and speciation. However, while this research has shown that the genomic landscapes of diversity and differentiation are usually highly heterogeneous, it has also led to the increasing realization that this heterogeneity may evolve under processes other than adaptation or speciation. In particular, instead of being an effect of selective sweeps or barriers to gene flow, accentuated differentiation can evolve by any process reducing genetic diversity locally within the genome (Charlesworth, ), including purifying selection at linked sites (background selection). In particular, in genomic regions where recombination is infrequent, accentuated differentiation can evolve as a by-product of diversity reductions unrelated to adaptation or spe...Continue Reading


May 15, 1998·Molecular Biology and Evolution·B Charlesworth
Dec 28, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael W Nachman, Bret A Payseur
Mar 13, 2013·Nature Reviews. Genetics·Asher D Cutter, Bret A Payseur
Sep 21, 2013·Genome Research·Simon H MartinChris D Jiggins
Apr 11, 2015·PLoS Biology·Russell B Corbett-DetigTimothy B Sackton
Aug 11, 2016·PLoS Genetics·Tanya N PhungKirk E Lohmueller
Sep 24, 2016·Molecular Biology and Evolution·Kasper MunchThomas Mailund
Mar 4, 2017·Molecular Ecology·Benjamin M Van DorenMiriam Liedvogel

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