Linking Biochemical and Structural States of SERCA: Achievements, Challenges, and New Opportunities.

International Journal of Molecular Sciences
Rodrigo Aguayo-Ortiz, L Michel Espinoza-Fonseca

Abstract

Sarcoendoplasmic reticulum calcium ATPase (SERCA), a member of the P-type ATPase family of ion and lipid pumps, is responsible for the active transport of Ca2+ from the cytoplasm into the sarcoplasmic reticulum lumen of muscle cells, into the endoplasmic reticulum (ER) of non-muscle cells. X-ray crystallography has proven to be an invaluable tool in understanding the structural changes of SERCA, and more than 70 SERCA crystal structures representing major biochemical states (defined by bound ligand) have been deposited in the Protein Data Bank. Consequently, SERCA is one of the best characterized components of the calcium transport machinery in the cell. Emerging approaches in the field, including spectroscopy and molecular simulation, now help integrate and interpret this rich structural information to understand the conformational transitions of SERCA that occur during activation, inhibition, and regulation. In this review, we provide an overview of the crystal structures of SERCA, focusing on identifying metrics that facilitate structure-based categorization of major steps along the catalytic cycle. We examine the integration of crystallographic data with different biophysical approaches and computational methods to link bio...Continue Reading

References

Jun 30, 1975·Biochimica Et Biophysica Acta·R N FaríasR E Trucco
Apr 5, 1991·Journal of Molecular Biology·G von Heijne
Jan 1, 1990·Proteins·J P SegrestG M Anantharamaiah
Mar 1, 1990·Journal of Molecular Graphics·G Vriend
Aug 21, 1986·Biochimica Et Biophysica Acta·R J FroudA G Lee
Nov 1, 1981·European Journal of Biochemistry·G von Heijne
Jun 27, 1998·Molecular and Chemical Neuropathology·F Baba-AissaR Casteels
Jul 2, 1998·Biophysical Journal·C N Pace, J M Scholtz
Feb 4, 1999·Biochemistry·G W HunterT C Squier
Dec 11, 1999·Nucleic Acids Research·H M BermanP E Bourne
Dec 22, 1999·Annals of the New York Academy of Sciences·D D ThomasJ Stamm
Sep 6, 2000·Trends in Biochemical Sciences·J A Killian, G von Heijne
Oct 25, 2000·Protein Science : a Publication of the Protein Society·A FiserA Sali
May 4, 2001·Biochimica Et Biophysica Acta·M B Ulmschneider, M S Sansom
Feb 7, 2002·Journal of Molecular Biology·Chen XuDavid L Stokes
Apr 20, 2002·Biophysical Journal·Markus EilersSteven O Smith
Aug 9, 2002·Nature·Chikashi Toyoshima, Hiromi Nomura
Apr 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Michio AsahiDavid H MacLennan
May 17, 2003·The Journal of Biological Chemistry·Hailun MaChikashi Toyoshima
Jan 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sarah YohannanJames U Bowie
Mar 27, 2004·Bioinformatics·Rasko LeinonenRolf Apweiler
Jun 12, 2004·Science·Thomas Lykke-Møller SørensenPoul Nissen
Jul 2, 2004·Nature·Chikashi Toyoshima, Tatsuaki Mizutani
Jul 13, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Federica Del MonteRoger J Hajjar
Sep 24, 2004·The Journal of Biological Chemistry·Thomas Lykke-Møller SørensenPoul Nissen
Nov 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Anthony O GramoliniDavid H MacLennan
Dec 25, 2004·Science·Claus OlesenPoul Nissen
Sep 10, 2005·Proceedings of the National Academy of Sciences of the United States of America·Koji ObaraChikashi Toyoshima
Sep 20, 2005·Biophysical Journal·Carmen DomeneDeclan A Doyle
Apr 1, 2006·Journal of Molecular Biology·Christine B KarimDavid D Thomas
May 20, 2006·The EMBO Journal·Anne-Marie Lund JensenPoul Nissen

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Citations

Sep 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Francesco Tadini-Buoninsegni
Oct 7, 2020·International Journal of Molecular Sciences·Rodrigo Aguayo-Ortiz, L Michel Espinoza-Fonseca
Jan 8, 2021·Journal of Hematology & Oncology·Luca PagliaroGiovanni Roti
Dec 31, 2020·International Journal of Molecular Sciences·Agata JaskulskaKatarzyna Gach-Janczak
Sep 22, 2020·Analytical Biochemistry·Joseph M AutryStephanie J Valberg
Apr 4, 2021·International Journal of Molecular Sciences·L Michel Espinoza-Fonseca
Oct 19, 2020·Biophysical Journal·Olga N RaguimovaL Michel Espinoza-Fonseca
Jul 24, 2021·ChemMedChem·Giacomo SordiFrancesco Tadini-Buoninsegni
Aug 11, 2021·Annual Review of Cell and Developmental Biology·Sheng Luan, Chao Wang

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Methods Mentioned

BETA
X-ray
electron microscopy
nucleotide exchange
fluorescence
FRET
acylation

Software Mentioned

GROMACS
PPM
PyMOL
MDAnalysis
Model
Swiss
WHAT IF
MODELLER
Gnuplot

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