PMID: 9651479Jul 4, 1998Paper

Linking cell-fate specification to planar polarity: determination of the R3/R4 photoreceptors is a prerequisite for the interpretation of the Frizzled mediated polarity signal

Mechanisms of Development
M FantoM Mlodzik

Abstract

The adult eye of Drosophila is a highly ordered structure composed of about 800 ommatidia, each displaying precise polarity. The planar polarity is reflected in the mirror-symmetric arrangement of ommatidia relative to the dorso-ventral midline, the equator. This arrangement is generated when ommatidia rotate towards the equator and the photoreceptor R3 displaces R4 creating different chiral forms in each half. Analysis of ommatidia mosaic for the tissue polarity gene frizzled (fz) has shown that the presence of a single Fz+ photoreceptor cell within the R3/ R4 pair is critical for the direction of rotation and chirality. By analysing clones mutant for seven-up (svp), in which R3/R4 precursors reside in their normal positions and become photoreceptor neurones but fail to adopt the normal R3/R4 fate, we find that the R3/R4 photoreceptor subtype specification is a prerequisite for planar polarisation in the eye. Moreover, in mosaic R3/R4 pairs we find that the svp- cell always adopts the R4 position. This bias is reminiscent of what happens in fz mosaic R3/R4 pairs, where the fz- cell also almost always adopts the R4 position. In addition, we find that in genotypes where too many cells adopt the R3/R4 fate, ommatidial polarity is...Continue Reading

References

Nov 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P N Adler
Mar 1, 1989·Trends in Neurosciences·D F Ready
May 15, 1997·Nature·D I StruttM Mlodzik
Jan 13, 1998·Current Opinion in Cell Biology·S Eaton
Apr 1, 1987·Developmental Biology·A Tomlinson, D F Ready

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Citations

Jun 23, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R Reifegerste, K Moses
Jul 2, 2010·Annual Review of Cell and Developmental Biology·Robert J Johnston, Claude Desplan
May 5, 2004·Médecine sciences : M/S·François Schweisguth
Aug 2, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Rebecca RockManfred Gessler
Dec 17, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Justin P Kumar
Jul 19, 2002·Current Biology : CB·Amy S RawlsTanya Wolff
Dec 14, 2002·Developmental Cell·Ya-Hui Chou, Cheng-Ting Chien
Nov 10, 2006·Critical Reviews in Biochemistry and Molecular Biology·David B Doroquez, Ilaria Rebay
Dec 31, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Matthew G Voas, Ilaria Rebay
Jan 1, 2013·Animals : an Open Access Journal From MDPI·Gabriele Berberich, Ulrich Schreiber

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