Linking Cellular Morphogenesis with Antifungal Treatment and Susceptibility in Candida Pathogens

Journal of Fungi
Jehoshua SharmaRebecca S Shapiro

Abstract

Fungal infections are a growing public health concern, and an increasingly important cause of human mortality, with Candida species being amongst the most frequently encountered of these opportunistic fungal pathogens. Several Candida species are polymorphic, and able to transition between distinct morphological states, including yeast, hyphal, and pseudohyphal forms. While not all Candida pathogens are polymorphic, the ability to undergo morphogenesis is linked with the virulence of many of these pathogens. There are also many connections between Candida morphogenesis and antifungal drug treatment and susceptibility. Here, we review how Candida morphogenesis-a key virulence trait-is linked with antifungal drugs and antifungal drug resistance. We highlight how antifungal therapeutics are able to modulate morphogenesis in both sensitive and drug-resistant Candida strains, the shared signaling pathways that mediate both morphogenesis and the cellular response to antifungal drugs and drug resistance, and the connection between Candida morphology, drug resistance, and biofilm growth. We further review the development of anti-virulence drugs, and targeting Candida morphogenesis as a novel therapeutic strategy to target fungal pathog...Continue Reading

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Citations

Sep 7, 2019·Current Protein & Peptide Science·Marianela Del RioMariana Regente
May 7, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Ifeanyi Elibe Mba, Emeka Innocent Nweze
Dec 5, 2019·Antibiotics·Antonia Thassya Lucas Dos SantosHenrique Douglas Melo Coutinho
May 28, 2019·F1000Research·Robert A Arkowitz, Martine Bassilana
Aug 6, 2020·Journal of Fungi·Callum J O'KaneEdel M Hyland
Sep 26, 2020·Current Protocols in Microbiology·Grace H KimRebecca S Shapiro
Jun 3, 2021·Antibiotics·Anne Caroline Morais CaldeirãoDouglas Roberto Monteiro
Oct 30, 2021·Frontiers in Genome Editing·Deeva UthayakumarRebecca S Shapiro
Dec 6, 2021·FEMS Yeast Research·Nicholas C GervaisRebecca S Shapiro

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