Linking Cigarette Smoking/Tobacco Exposure and Cluster Headache: A Pathogenesis Theory

Headache
Todd D Rozen

Abstract

To propose a hypothesis theory to establish a linkage between cigarette smoking and cluster headache pathogenesis. Cluster headache is a primary headache syndrome grouped under the trigeminal autonomic cephalalgias. What distinguishes cluster headache from all other primary headache conditions is its inherent connection to cigarette smoking. It is undeniable that tobacco exposure is in some manner related to cluster headache. The connection to tobacco exposure for cluster headache is so strong that even if an individual sufferer never smoked, then that individual typically had significant secondary smoke exposure as a child from parental smoking behavior and in many instances both scenarios exist. The manner by which cigarette smoking is connected to cluster headache pathogenesis is unknown at present. If this could be determined this may contribute to advancing our understanding of cluster headache pathophysiology. Hypothesis statement. The hypothesis theory will include several principles: (1) the need of double lifetime tobacco exposure, (2) that cadmium is possibly the primary agent in cigarette smoke that leads to hypothalamic-pituitary-gonadal axis toxicity promoting cluster headache, (3) that the estrogenization of the b...Continue Reading

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Jul 2, 2019·Cephalalgia : an International Journal of Headache·Todd D Rozen

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