Linking Circulating Serum Proteins with Clinical Outcomes in Esophageal Adenocarcinoma-An Emerging Role for Chemokines

Cancers
Noel E DonlonMargaret R Dunne

Abstract

Esophageal adenocarcinoma (EAC) is an aggressive cancer with poor prognosis and incidence is increasing rapidly in the Western world. Multi-modal treatment has improved survival outcomes but only for a minority of patients. Currently no markers have been identified to predict treatment response. This study investigated the association between clinical outcomes and pre-treatment levels of 54 serum proteins in n = 80 patients with EAC. Low tumor regression grade (TRG), corresponding to a favorable treatment response, was linked to prolonged overall survival (OS). CCL4 was higher in patients with a favorable treatment response, while Tie2 and CRP were higher in poor responders. Elevated CCL22 and CCL26 was associated with improved OS, while elevated IL-10 showed a negative association. CCL3, CCL4, IL-1α and IL-12/IL23p40 were highest in individuals with no adverse features of tumor biology, whereas levels of Tie2 and VEGF were lowest in this cohort. CCL4 was also elevated in patients with high tumor lymphocyte infiltration. Comparison of matched pre- and post-treatment serum (n = 28) showed a large reduction in VEGFC, and a concomitant increase in other cytokines, including CCL4. These data link several serum markers with clinical...Continue Reading

References

Jan 1, 1996·The British Journal of Surgery·S Y LawJ Wong
Dec 31, 1998·The New England Journal of Medicine·D P KelsenJ A Roth
May 4, 2005·Onkologie·Axel KleespiesKarl-Walter Jauch
Nov 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christie BarclayAlan G Casson
Feb 3, 2006·The Journal of Clinical Investigation·Carine BlanchardMarc E Rothenberg
Jul 11, 2006·The New England Journal of Medicine·David Cunningham MAGIC Trial Participants
Aug 21, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David P KelsenUNKNOWN USA Intergroup
Nov 5, 2010·Molecular Cancer Research : MCR·Ellen Margrethe HaugstenJørgen Wesche
Jun 21, 2011·The Lancet Oncology·Katrin M SjoquistUNKNOWN Australasian Gastro-Intestinal Trials Group
Jun 28, 2011·Gut·William H AllumUNKNOWN Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland, the British Society of Gastroenterology and the
Jan 11, 2013·Cancer·Chin HurEric J Feuer
Jan 11, 2014·World Journal of Gastroenterology : WJG·Fergus NobleAndrew R Bateman
Oct 15, 2014·Cancer Letters·Nikolett M Biel, Dietmar W Siemann
Jan 22, 2015·International Journal of Cancer. Journal International Du Cancer·Mi ZhouJohn K Wiencke
Feb 28, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·A JafarzadehA Ghaderi
Jun 25, 2015·Nature Reviews. Cancer·Holly E BarkerKevin J Harrington
Oct 31, 2015·Science·Erika VacchelliGuido Kroemer
Mar 24, 2016·Journal of Surgical Oncology·Siun M WalshJohn V Reynolds
Mar 30, 2016·Cancer Immunology, Immunotherapy : CII·Fergus NobleChristian H Ottensmeier
Jun 15, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elizabeth C SmythNicola Valeri
Dec 22, 2016·Oncoimmunology·Evelina MartinenaiteMads Hald Andersen
Jul 28, 2017·Nature Reviews. Disease Primers·Elizabeth C SmythDavid Cunningham
Sep 18, 2017·Virchows Archiv : an International Journal of Pathology·Rupert Langer, Karen Becker
Mar 6, 2019·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Maria E KavanaghJoanne Lysaght
Mar 11, 2019·Gut·Richard C TurkingtonUNKNOWN Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Study Group
Mar 16, 2019·Frontiers in Immunology·Anna E Vilgelm, Ann Richmond
Aug 7, 2019·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Zhixiang LiChao Zhu

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Citations

Aug 1, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Rhiannon McShaneMark Bates

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Methods Mentioned

BETA
surgical resection
biopsy
ELISA
enzyme-linked immunosorbent assay

Software Mentioned

R package “ Hmisc ”
Meso Scale Diagnostics Discovery Workbench
R package “ CorrPlot ”
R
SPSS
Prism GraphPad

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