Jun 11, 2011

Linking inflammation and coagulation: novel drug targets to treat organ ischemia

Current Opinion in Anaesthesiology
Carla JenneweinKai Zacharowski

Abstract

Activation of the coagulation system during ischemia/reperfusion injury is an unavoidable event and even further augmented during cardiovascular surgery. Clotting not only leads to disturbance of blood rheology but also enhances the inflammatory response. We aim to highlight the inflammatory properties of the coagulation system and novel potential therapeutic approaches targeting both features. Heparin, a thrombin inhibitor, is still the drug of choice for preventing coagulation following, for example, cardiovascular surgery. On the contrary, much effort is done to evaluate the utilization of direct thrombin inhibitors to prevent ischemia/reperfusion injury. Furthermore, targeting the inflammatory potential of the coagulation system seems to be very promising. Fibrin(ogen) and its degradation products modulate the inflammatory response, especially by inducing leukocyte migration. Inhibiting these pro-inflammatory effects, for example, by administration of Bβ15-42 was recently shown to be beneficial under various inflammatory conditions. Ischemia and reperfusion are common activators of coagulation that is also accompanied by inflammation. Therefore, targeting this well orchestrated system might be of therapeutic benefit, as its...Continue Reading

Mentioned in this Paper

Ischemia
Fibrin Measurement
Heparin
Systemic Inflammatory Response Syndrome
F2 gene
Thrombin
Myopathy
Liquaemin
Blood Coagulation Disorders
Cardiopulmonary Bypass

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Mark S SlaughterRobert Stein
ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Theodor TirilomisFriedrich A Schoendube
ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
R HouëlD Loisance
ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Angela N BartleyMary P Berg
© 2020 Meta ULC. All rights reserved