Linking integrin conformation to function.

Journal of Cell Science
Janet A AskariMartin J Humphries

Abstract

Integrins are alphabeta heterodimeric adhesion receptors that relay signals bidirectionally across the plasma membrane between the extracellular matrix and cell-surface ligands, and cytoskeletal and signalling effectors. The physical and chemical signals that are controlled by integrins are essential for intercellular communication and underpin all aspects of metazoan existence. To mediate such diverse functions, integrins exhibit structural diversity, flexibility and dynamism. Conformational changes, as opposed to surface expression or clustering, are central to the regulation of receptor function. In recent years, there has been intense interest in determining the three-dimensional structure of integrins, and analysing the shape changes that underpin the interconversion between functional states. Considering the central importance of the integrin signalling nexus, it is perhaps no surprise that obtaining this information has been difficult, and the answers gained so far have been complicated. In this Commentary, we pose some of the key remaining questions that surround integrin structure-function relationships and review the evidence that supports the current models.

References

Mar 22, 1996·The Journal of Biological Chemistry·P E HughesM H Ginsberg
Apr 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C LuT A Springer
Apr 27, 2001·Nature Structural Biology·J TakagiT A Springer
Mar 16, 2002·Nature Structural Biology·Natalia BeglovaTimothy A Springer
May 4, 2002·Annual Review of Biophysics and Biomolecular Structure·Motomu ShimaokaTimothy A Springer
Sep 18, 2002·Immunological Reviews·Junichi Takagi, Timothy A Springer
Oct 22, 2002·Proceedings of the National Academy of Sciences of the United States of America·Brian D Adair, Mark Yeager
Jan 22, 2003·Molecular Cell·Begoña García-AlvarezRobert C Liddington
Jul 23, 2003·The Journal of Biological Chemistry·A Paul MouldMartin J Humphries
Sep 13, 2003·The EMBO Journal·Junichi TakagiThomas Walz
Oct 4, 2003·Science·Seiji TadokoroDavid A Calderwood
Dec 4, 2003·Biophysical Journal·Alexandre ChigaevLarry A Sklar
Feb 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Wei YangTimothy A Springer
Sep 15, 2004·Current Opinion in Cell Biology·A Paul Mould, Martin J Humphries
May 3, 2005·The Journal of Biological Chemistry·Tetsuji KamataSadakazu Aiso
May 14, 2005·Journal of Structural Biology·Kenji IwasakiTakao Yamada
Aug 15, 2006·Current Opinion in Cell Biology·Bing-Hao Luo, Timothy A Springer
Sep 19, 2006·Current Biology : CB·Jaewon HanMark H Ginsberg
Sep 27, 2006·The Journal of Cell Biology·Wendy Thomas
Oct 25, 2006·The Journal of Cell Biology·Eileen Puklin-FaucherViola Vogel
Dec 13, 2006·Biochemistry·Nathan S AstrofTimothy A Springer
Jan 16, 2007·Cell·Kate L WegenerIain D Campbell
May 3, 2007·Protein Science : a Publication of the Protein Society·Clare J McClevertyRobert C Liddington
May 22, 2007·The Journal of Biological Chemistry·Xiaohua ShiChuanyue Wu
May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexandre ChigaevLarry A Sklar
Oct 12, 2007·Current Opinion in Cell Biology·M Amin ArnaoutJian-Ping Xiong
Dec 25, 2007·The Journal of Biological Chemistry·Camilla L OxleyKate L Wegener
Apr 18, 2008·The Journal of Biological Chemistry·Tong-Lay LauTobias S Ulmer

❮ Previous
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Citations

Aug 21, 2009·Cell and Tissue Research·Malgorzata BarczykDonald Gullberg
Jul 30, 2009·The Journal of Biological Chemistry·Rosemary BassVincent Ellis
Jan 6, 2010·The Journal of Biological Chemistry·Syed M AhmedStephane Angers
Jul 31, 2010·The Journal of Biological Chemistry·Benoit J SmaggheTimothy A Springer
Dec 14, 2011·The Journal of Biological Chemistry·Xian M O'BrienJonathan S Reichner
Mar 23, 2011·Cold Spring Harbor Perspectives in Biology·Iain D Campbell, Martin J Humphries
Sep 9, 2011·Cold Spring Harbor Perspectives in Biology·John S Munger, Dean Sheppard
May 21, 2013·Journal of Bacteriology·Elaine WoodMaria D Esteve-Gassent
Oct 9, 2013·Annual Review of Cell and Developmental Biology·Tadanori MammotoDonald E Ingber
Feb 19, 2010·American Journal of Physiology. Cell Physiology·Iva NeveuxMaria L Valencik
Mar 29, 2011·American Journal of Respiratory Cell and Molecular Biology·Mats W Johansson, Deane F Mosher
Jan 12, 2013·American Journal of Respiratory Cell and Molecular Biology·Mats W JohanssonDeane F Mosher
Mar 13, 2010·Fibrogenesis & Tissue Repair·Beate EckesThomas Krieg
Jun 21, 2013·Fibrogenesis & Tissue Repair·Ariel Bing-Shi TanMichael Raghunath
Mar 25, 2010·Journal of Cell Science·Bethsaida NievesSusan E LaFlamme
Oct 26, 2010·Journal of Cell Science·DeannaLee M Beauvais, Alan C Rapraeger
Mar 22, 2013·PLoS Computational Biology·Mehrdad Mehrbod, Mohammad R K Mofrad
Mar 29, 2014·Advances in Wound Care·Whitney M Longmate, C Michael Dipersio
Feb 4, 2014·BioMed Research International·Jui-Chieh ChenChih-Hsin Tang
Jun 20, 2014·Science Translational Medicine·Shunsuke MinagawaStephen L Nishimura
Jan 17, 2012·Cellular and Molecular Bioengineering·Daniela E FuentesPeter J Butler
Mar 15, 2013·Cellular and Molecular Bioengineering·Daniela E Fuentes, Peter J Butler
Dec 3, 2014·Pharmacology & Therapeutics·Ioannis MitroulisTriantafyllos Chavakis
Jun 19, 2013·Nanomedicine : Nanotechnology, Biology, and Medicine·Peter NewmanHala Zreiqat
Oct 9, 2015·Molecular Biology of the Cell·Guðlaug Katrín HákonardóttirGuy Tanentzapf
Jun 19, 2012·European Journal of Cell Biology·Asier Jayo, Maddy Parsons
Jan 11, 2011·Trends in Biochemical Sciences·Nicholas J Anthis, Iain D Campbell
Jul 6, 2010·Experimental Cell Research·Soon-Mi LimAndreea Trache
Jun 29, 2010·Experimental Cell Research·Mary Ann SteppMelinda Larsen
Mar 23, 2010·Experimental Cell Research·Marie K SchwinnDonna M Peters
Dec 1, 2009·Dermatologic Clinics·Myung S Ko, M Peter Marinkovich
Mar 21, 2009·Biochimica Et Biophysica Acta·Sophia W M BruggemanMaarten van Lohuizen

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