Feb 19, 2017

Linking long non-coding RNAs and SWI/SNF complexes to chromatin remodeling in cancer

Molecular Cancer
Yanyan TangZhaoyang Zeng

Abstract

Chromatin remodeling controls gene expression and signaling pathway activation, and aberrant chromatin structure and gene dysregulation are primary characteristics of human cancer progression. Recent reports have shown that long non-coding RNAs (lncRNAs) are tightly associated with chromatin remodeling. In this review, we focused on important chromatin remodelers called the switching defective/sucrose nonfermenting (SWI/SNF) complexes, which use the energy of ATP hydrolysis to control gene transcription by altering chromatin structure. We summarize a link between lncRNAs and the SWI/SNF complexes and their role in chromatin remodeling and gene expression regulation in cancer, thereby providing systematic information and a better understanding of carcinogenesis.

Mentioned in this Paper

Gene Expression Regulation, Neoplastic
Chromosomal Proteins, Non-Histone
RNA, Untranslated
Complex (molecular entity)
Transcription, Genetic
Cancer Progression
Signal Transduction Pathways
SPT6 Protein
Plasma Protein Binding Capacity
Gene Expression

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