Linking Mitochondria to Synapses: New Insights for Stress-Related Neuropsychiatric Disorders

Neural Plasticity
Freddy D Jeanneteau, Margarita Arango-Lievano

Abstract

The brain evolved cellular mechanisms for adapting synaptic function to energy supply. This is particularly evident when homeostasis is challenged by stress. Signaling loops between the mitochondria and synapses scale neuronal connectivity with bioenergetics capacity. A biphasic "inverted U shape" response to the stress hormone glucocorticoids is demonstrated in mitochondria and at synapses, modulating neural plasticity and physiological responses. Low dose enhances neurotransmission, synaptic growth, mitochondrial functions, learning, and memory whereas chronic, higher doses produce inhibition of these functions. The range of physiological effects by stress and glucocorticoid depends on the dose, duration, and context at exposure. These criteria are met by neuronal activity and the circadian, stress-sensitive and ultradian, stress-insensitive modes of glucocorticoid secretion. A major hallmark of stress-related neuropsychiatric disorders is the disrupted glucocorticoid rhythms and tissue resistance to signaling with the glucocorticoid receptor (GR). GR resistance could result from the loss of context-dependent glucocorticoid signaling mediated by the downregulation of the activity-dependent neurotrophin BDNF. The coincidence o...Continue Reading

References

Jul 25, 1990·Biochimica Et Biophysica Acta·J G McCormack, R M Denton
Jun 1, 1982·The Journal of Clinical Investigation·G P ChrousosM B Lipsett
Dec 1, 1993·Annals of Internal Medicine·G P ChrousosM Karl
Apr 1, 1996·Steroids·C V DemonacosC E Sekeris
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·K WuP Siekevitz
Oct 12, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·F Holsboer
Feb 22, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J L MadrigalJ C Leza
Mar 20, 2001·Nature Reviews. Neuroscience·M M Poo
Oct 13, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D Attwell, S B Laughlin
Jan 15, 2003·Experimental Physiology·Klaus Scheller, Constantine E Sekeris
Feb 1, 2003·Neurobiology of Learning and Memory·Benno Roozendaal
Mar 5, 2003·Hormones and Behavior·Bruce S McEwen, John C Wingfield
Mar 5, 2003·Hormones and Behavior·Glenn E Walsberg
Aug 22, 2003·Molecular Psychiatry·A MorettiR F Villa
Sep 3, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jacques J LaschetRené Pumain
Sep 17, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benno RoozendaalJames L McGaugh
Oct 21, 2004·Nature Neuroscience·Giles S H YeoI Sadaf Farooqi
Nov 16, 2004·Nature Neuroscience·Arianna MaffeiGina G Turrigiano
May 14, 2005·Nature Reviews. Neuroscience·E Ron de KloetFlorian Holsboer
Sep 1, 2005·Neuron·Tara C ThiagarajanRichard W Tsien
Oct 15, 2005·Nature Reviews. Neuroscience·Zane B AndrewsTamas L Horvath
Dec 1, 2005·Trends in Immunology·Charles L RaisonAndrew H Miller
Jan 5, 2006·The Journal of Experimental Medicine·Ronit Vogt SionovEitan Yefenof
Jan 24, 2006·Nature Reviews. Neuroscience·Olivier Berton, Eric J Nestler
Apr 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Benno RoozendaalJames L McGaugh
Apr 25, 2006·Biological Psychiatry·Ronald S Duman, Lisa M Monteggia
May 10, 2006·Ageing Research Reviews·Thiruma V ArumugamMark P Mattson
Jun 30, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Diane T W ChangIan J Reynolds
Jul 28, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Conor ListonBruce S McEwen
Jul 28, 2006·American Journal of Physiology. Cell Physiology·Allen KaasikVladimir Veksler
Aug 2, 2006·Annual Review of Pharmacology and Toxicology·D Grahame Hardie

❮ Previous
Next ❯

Citations

Sep 24, 2016·Journal of Alzheimer's Disease : JAD·Lan GuoHeng Du
Nov 17, 2016·Scientific Reports·Margarita Arango-LievanoFreddy Jeanneteau
Mar 8, 2018·The International Journal of Neuropsychopharmacology·Fenghua ChenJens R Nyengaard
Jan 10, 2018·Frontiers in Molecular Neuroscience·Emma PuighermanalEmmanuel Valjent
Sep 3, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David G HarperDan V Iosifescu
Sep 25, 2017·Perspectives on Psychological Science : a Journal of the Association for Psychological Science·Peter Kramer, Paola Bressan
Aug 2, 2018·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Kathryn K RidoutSamuel J Ridout
Dec 12, 2017·The International Journal of Neuropsychopharmacology·Fenghua ChenJens R Nyengaard
Aug 7, 2017·F1000Research·Michael J GarabedianFreddy Jeanneteau
Oct 16, 2018·Frontiers in Molecular Neuroscience·Wibke SingerMarlies Knipper
Mar 6, 2019·International Neurourology Journal·Jason TangMi-Hyeon Jang
Mar 17, 2019·Cerebral Cortex·Melissa Taylor-GiorlandoTamas L Horvath
Aug 22, 2018·Frontiers in Molecular Neuroscience·Lucas MattWibke Singer
Sep 16, 2017·Neurochemical Research·Carina de Souza MotaLetícia Ferreira Pettenuzzo
Dec 17, 2018·Chemico-biological Interactions·Evgenios AgathokleousEdward J Calabrese
Jul 3, 2019·Journal of Cell Science·Dina S Coelho, Eduardo Moreno
May 11, 2021·American Journal of Physiology. Endocrinology and Metabolism·Hsiu-Mei HuangKay L H Wu
Jul 3, 2021·International Journal of Molecular Sciences·Serena AsslihGalila Agam
Jul 3, 2021·Cells·Miguel A Gonzalez-LozanoKa Wan Li
Jul 3, 2021·International Journal of Molecular Sciences·Ioanna Kokkinopoulou, Paraskevi Moutsatsou
Aug 8, 2017·Neurochemistry International·Shannon ChiangMichael L-H Huang

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPases
electron microcopy

Related Concepts

Related Feeds

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Caspases in Metabolic Diseases

Caspases, the family of cysteine proteases are involved in programmed cell death, but their role in metabolic diseases, inflammation and immunity has been of interested. Discover the latest research on caspases in metabolic diseases here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Genetics & Epigenetics of Aging

Dozens of genes are implicated in lifespan, and epigenetic changes during aging affect cell function. This feed focuses on the genetics and epigenetics of aging.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.