Linking morphological and functional variability in hand movement and silent reading

Brain Structure & Function
Z Y SunJ-F Mangin

Abstract

It is generally accepted in neuroscience that anatomy and function go hand in hand. Accordingly, a local morphological variability could lead to a corresponding functional variability. In this study, we tested this hypothesis by linking the variability of the cortical folding pattern of 252 right-handed subjects to the localization or the pattern of functional activations induced by hand motion or silent reading. Three regions are selected: the central sulcus, the precentral sulcus and the superior temporal sulcus (STS). "Essential morphological variability traits" are identified using a method building upon multidimensional scaling. The link between variability in anatomy and function is confirmed by the perfect match between the central sulcus morphological "hand knob" and the corresponding motor activation: as the location of the hand knob moves more or less dorsally along the central sulcus, the motor hand activation moves accordingly. Furthermore, the size of the left hand activation in the right hemisphere is correlated with the knob location in the central sulcus. A new link between functional and morphological variability is discovered relative to the location of a premotor activation induced by silent reading. While th...Continue Reading

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Citations

Jun 28, 2016·Medical Image Analysis·J-F ManginZ Y Sun
Apr 18, 2018·Nature Ecology & Evolution·Stilianos LoucaLaura Wegener Parfrey
Aug 2, 2017·Brain Structure & Function·C BodinO Coulon
Oct 5, 2019·Brain Topography·Jean-François ManginZhong Yi Sun
Sep 2, 2016·Frontiers in Human Neuroscience·Charles MellerioArnaud Cachia
Nov 28, 2020·Brain Structure & Function·Alexandre PronOlivier Coulon
Dec 24, 2020·Brain Structure & Function·Nicole EichertMichael Petrides
May 8, 2019·NeuroImage·Philippe PinelCyril Poupon
Jun 6, 2021·NeuroImage·Léonie BorneJean-François Mangin
Aug 11, 2021·Brain Structure & Function·Laszlo Zaborszky

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